ReviewMolecular and cellular biochemistry2022
Fallopian tubal infertility: the result of Chlamydia trachomatis-induced fallopian tubal fibrosis.
Review in Molecular and cellular biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 15 citations in OpenAlex.
- Comparison of the Diagnostic Consistency between Delayed Radiographs taken Two Hours and Twenty-four Hours Post Hysterosalpingography using Ultra-Fluid Lipiodol-based Contrast MediumCurrent medical imaging · 2026Trial
- Wnt/Notch Crosstalk Promotes Epithelial-Mesenchymal Transition DuringMicroorganisms · 2026Article
- Review
- Molecular insights into salpingitis-induced infertility and ectopic pregnancy: pathogenesis, biomarkers, and translational perspectives.Archives of gynecology and obstetrics · 2026Review
- Article
- Global, Regional, and National Burden of Female Infertility Attributable to Chlamydia Infections, 1990-2023: An Analysis Based on the Global Burden of Disease Study 2023.International journal of women's health · 2026Article
- Interactive Effect of C-Reactive Protein upon the Relationship BetweenDiagnostics (Basel, Switzerland) · 2025Article
- Review
- Insights into innate immune cell evasion byFrontiers in immunology · 2024Review
- Human umbilical cord mesenchymal stem cells derived extracellular vesicles alleviate salpingitis by promoting M1-to-M2 transformation.Frontiers in physiology · 2023Article
- Scanning electron microscopic study of the human uterine tube epithelial lining: surgical biopsy samples and epithelial cell culture.Physiological research · 2022Article
- Prevalence of Human Papillomavirus Infection in the Female Partner of Infertile Couples Undergoing IVF/ICSI-ET and Subsequent Reproductive Outcomes.Journal of clinical medicine · 2022Article
- Improvement of fertility outcomes using dexamethasone / antibiotic adjuvant therapy following hysterosalpingography in infertile females: A randomised trial.Pakistan journal of medical sciencesArticle
- Role of microRNAs in immune regulation and pathogenesis of Chlamydia trachomatis and Chlamydia muridarum infections: a rapid review.Microbes and infectionReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chlamydia trachomatis is one of the most common pathogens of sexually transmitted diseases, and its incidence in genital tract infections is now 4.7% in south China. Infertility is the end result of C. trachomatis-induced fallopian tubal fibrosis and is receiving intense attention from scientists worldwide. To reduce the incidence of infertility, it is important to understand the pathology-related changes of the genital tract where C. trachomatis infection is significant, especially the mechanism of fibrosis formation. During fibrosis development, the fallopian tube becomes sticky and occluded, which will eventually lead to tubal infertility. At present, the mechanism of fallopian tubal fibrosis induced by C. trachomatis infection is unclear. Our study attempted to summarize the possible mechanisms of fibrosis caused by C. trachomatis infection in the fallopian tube by reviewing published studies and further providing potential therapeutic targets to reduce the occurrence of infertility. This study also provides ideas for future research. Factors leading to fallopian tube fibrosis include inflammatory factors, miRNA, ECT, cHSP, and host factors. We hypothesized that C. trachomatis mediates the transcription and translation of EMT and ECM via upregulating TGF signaling pathway, which leads to the formation of fallopian tube fibrosis and ultimately to tubal infertility.
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