Evidence map›Paper›PMID 34652502›Full record

ArticleJournal of neurology2022

The impact of the UK COVID-19 pandemic on patient-reported health outcomes after stroke: a retrospective sequential comparison.

Hatice Ozkan, Gareth Ambler, Gargi Banerjee, Edgar Chan, Simone Browning, John Mitchell, Richard Perry, Alex P Leff, Robert J Simister, David J Werring and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Acute Stroke Care during COVID-19: National Data.Infectious disease reports · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Hatice OzkanStroke Research Centre, Queen Square Institute of Neurology, University College London, London, UK.
Gareth AmblerDepartment of Statistical Science, University College London, Gower Street, London, UK.
Gargi BanerjeeMRC Prion Unit at UCL, Institute of Prion Diseases, University College London, London, UK.
Edgar ChanStroke Research Centre, Queen Square Institute of Neurology, University College London, London, UK.
Simone BrowningStroke Research Centre, Queen Square Institute of Neurology, University College London, London, UK.
John MitchellStroke Research Centre, Queen Square Institute of Neurology, University College London, London, UK.
Richard PerryStroke Research Centre, Queen Square Institute of Neurology, University College London, London, UK.
Alex P LeffStroke Research Centre, Queen Square Institute of Neurology, University College London, London, UK.
Robert J SimisterStroke Research Centre, Queen Square Institute of Neurology, University College London, London, UK.
David J WerringStroke Research Centre, Queen Square Institute of Neurology, University College London, London, UK. d.werring@ucl.ac.uk.ORCID http://orcid.org/0000-0003-2074-1861
SIGNaL collaborators
University College London Hospitals NHS Foundation Trust · GBNational Hospital for Neurology and Neurosurgery · GBMRC Prion Unit · GBUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeThe COVID-19 pandemic and related social isolation measures are likely to have adverse consequences on community healthcare provision and outcome after acute illnesses treated in hospital, including stroke. We aimed to evaluate the impact of the COVID-19 pandemic on patient-reported health outcomes after hospital admission for acute stroke.

methodsThis retrospective study included adults with acute stroke admitted to the University College Hospital NHS Foundation Trust Hyperacute Stroke Unit. We included two separate cohorts of consecutively enrolled patients from the same geographical population at two time points: 16th March-16th May 2018 (pre-COVID-19 pandemic); and 16th March-16th May 2020 (during the COVID-19 pandemic). Patients in both cohorts completed the validated Patient Reported Outcomes Measurement Information System-29 (PROMIS-29 version 2.0) at 30 days after stroke.

resultsWe included 205 patients who were alive at 30 days (106 admitted before and 99 admitted during the COVID-19 pandemic), of whom 201/205 (98%) provided patient-reported health outcomes. After adjustment for confounding factors, admission with acute stroke during the COVID-19 pandemic was independently associated with increased anxiety (β = 28.0, p < 0.001), fatigue (β = 9.3, p < 0.001), depression (β = 4.5, p = 0.002), sleep disturbance (β = 2.3, p = 0.018), pain interference (β = 10.8, p < 0.001); and reduced physical function (β = 5.2, p < 0.001) and participation in social roles and activities (β = 6.9, p < 0.001).

conclusionCompared with the pre-pandemic cohort, patients admitted with acute stroke during the first wave of the COVID-19 pandemic reported poorer health outcomes at 30 day follow-up in all domains. Stroke service planning for any future pandemic should include measures to mitigate this major adverse impact on patient health.

Indexed as

COVID-19StrokeAdultHumansOutcome Assessment, Health CarePandemicsPatient Reported Outcome MeasuresRetrospective StudiesSARS-CoV-2United KingdomCOVID-19Intracerebral haemorrhageIschaemic strokePatient-reported health outcomesStroke

Identifiers

PMID34652502
PMCPMC8517937
OpenAlexW3205208206

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.