ArticleInternational journal of epidemiology2022
How blood pressure predicts frailty transitions in older adults in a population-based cohort study: a multi-state transition model.
Article in International journal of epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global Prevalence and Factors Associated with Frailty among Community-Dwelling Older Adults with Hypertension: A Systematic Review and Meta-Analysis.The journal of nutrition, health & aging · 2023Pooled it
- Modeling multistage transition probability in blood pressure progression stages among hypertensive patients, southern Ethiopia: A retrospective cohort study.Journal of public health research · 2026Article
- Blood pressure satisfaction and antihypertensive medication adherence effects frailty transitions in older hypertensive patients.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Motoric Cognitive Risk Syndrome Associated With Risk of Frailty and Likelihood of Reversion in Older Adults.Journal of cachexia, sarcopenia and muscle · 2025Article
- Splenic and portal venous flow associated with frailty and sarcopenia in older outpatients with cardiovascular disease.BMC geriatrics · 2025Article
- Office and home blood pressure and their difference according to frailty status among community-dwelling older adults: the NOSE study.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Causal effects of blood pressure and the risk of frailty: a bi-directional two-sample Mendelian randomization study.Journal of human hypertension · 2024Article
- Differential effects of size-specific particulate matter on frailty transitions among middle-aged and older adults in China: findings from the China Health and Retirement Longitudinal Study (CHARLS), 2015-2018.International health · 2024Article
- Associations Between Frailty and the Increased Risk of Adverse Outcomes Among 38,950 UK Biobank Participants With Prediabetes: Prospective Cohort Study.JMIR public health and surveillance · 2023Article
- The Association Between Cardiometabolic Risk Factors and Frailty in Older Adults: A Systematic Review.Innovation in aging · 2022Review
- Use of a multistate model in survival predictions in cardiology studies.REC, interventional cardiologyArticle
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundLow blood pressure (BP) is associated with frailty in older adults. Our aim was to explore how BP predicts transitions between frailty states.
methodsWe used data from the Lausanne cohort Lc65+, a population-based cohort of older adults randomly drawn from a population registry in Switzerland, in 2004, 2009 and 2014. BP was measured using a clinically validated oscillometric automated device and frailty was defined using Fried's phenotype, every 3 years. We used an illness-death discrete multi-state Markov model to estimate hazard ratios of forward and backward transitions between frailty states (outcome) in relation to BP categories (predictor of interest) with adjustment for sex, age and antihypertensive medication (other predictors).
resultsAmong 4200 participants aged 65-70 years (58% female) at baseline, 70% were non-frail, 27% pre-frail and 2.0% frail. Over an average follow-up of 5.8 years, 2422 transitions were observed, with 1575 (65%) forward and 847 (35%) backward. Compared with systolic BP (SBP) <130 mmHg, the hazard ratio (95% confidence interval) of the transition from non-frail to pre-frail was 0.86 (0.74 to 1.00) for SBP 130-150 mmHg, and 0.89 (0.74 to 1.06) for SBP ≥150 mmHg. Compared with SBP <130 mmHg, the hazard ratio of the transition from pre-frail to frail was 0.71 (0.50 to 1.01) for SBP 130-150 mmHg, and 0.90 (0.62 to 1.32) for SBP ≥150 mmHg. Diastolic BP was a weaker predictor of forward transitions.
conclusionsBP categories had no strong relationship with either forward transitions or backward transitions in frailty states. If our findings are confirmed with greater precision and assuming a causal relationship, they would suggest that there is no well-defined optimal BP level to prevent frailty among older adults.
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