Evidence map›Paper›PMID 34652268›Full record

GuidelineAmerican journal of respiratory and critical care medicine2021

A Research Agenda for Precision Medicine in Sepsis and Acute Respiratory Distress Syndrome: An Official American Thoracic Society Research Statement.

Faraaz Ali Shah, Nuala J Meyer, Derek C Angus, Rana Awdish, Élie Azoulay, Carolyn S Calfee, Gilles Clermont, Anthony C Gordon, Arthur Kwizera, Aleksandra Leligdowicz and 7 more

3 registry-linked trialsOpen access · greenAbstract readGuideline
In one paragraph

Guideline in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 51 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 2 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05392010 unknown statusnot on this mapstarted 2022, after this paper: background citation

Assessment of Clinical Practice of Mechanical Ventilation After COVID-19 Pan-demic Among 57 Countries: A Systematic Analysis for the Global BurdEn of Me-chanIcal VeNtilatIon (GEMINI Study) 2022, From VENTILAGROUP.

Typeobservational_patient_registrySponsorHospital Universitario GetafeRan2022 to 2024Enrolled10,900ConditionsMechanical Ventilation, Usual Care, Noninvasive Positive Pressure Ventilation, High Flow Oxygen TherapyArmsno intervention
NCT05591924 recruitingnot on this mapstarted 2024, after this paper: background citation

Prospective Observational Study of Biology of Critical Illness

Typeobservational_patient_registrySponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2024 to 2034Enrolled1,000ConditionsSepsis, ARDS, Critical Illness, Neurocognitive DysfunctionArmsPhelebotomy, Broncheoalveolar Lavage, Tracheal Aspirate, Rectal Swab
NCT06123962 recruitingnot on this mapstarted 2023, after this paper: background citation

Acute Lung/ Acute Respiratory Distress Syndrome and Extra-pulmonary Organ Injury Clinical Sub-phenotyping Study

TypeobservationalSponsorChina-Japan Friendship HospitalRan2023 to 2025Enrolled1,500ConditionsAcute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)ArmsCollect peripheral blood and bronchoalveolar lavage fluid
3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 80 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
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  5. Review
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  14. Integrative omics and multi-cohort identifyJournal of biomedical research · 2025
    Article
  15. Observational
  16. Review
  17. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Carolyn S Calfee
Aleksandra LeligdowiczORCID 0000-0001-6055-4644
John C Marshall
Balasubramanian VenkateshORCID 0000-0002-3234-5244
Fernando G ZampieriORCID 0000-0001-9315-6386
American Thoracic Society · US

Funding

Precision Medicine in the Acute Respiratory Distress SyndromeR35HL140026 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CALFEE, CAROLYN · 2018 to 2024
$6.8M
NHLBI NIH HHS R35 HL140026
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Biomedical ResearchCritical CareHumansObservational Studies as TopicPrecision MedicineRandomized Controlled Trials as TopicRespiratory Distress SyndromeSepsisacute respiratory distress syndromeprecision medicinesepsis

Identifiers

PMID34652268
PMCPMC8534611
OpenAlexW3205250645

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.