Evidence map›Paper›PMID 34652258›Full record

ArticleBioengineered2021

Role of ferroptosis-related genes in Stanford type a aortic dissection and identification of key genes: new insights from bioinformatic analysis.

Hua-Xi Zou, Bai-Quan Qiu, Song-Qing Lai, Huang Huang, Xue-Liang Zhou, Cheng-Wu Gong, Li-Jun Wang, Ming-Ming Yuan, An-Di He, Ji-Chun Liu

Open access · goldAbstract read
In one paragraph

Article in Bioengineered, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  3. Review
  4. Review
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  6. Review
  7. [Research progress on the role of ferroptosis in aortic dissection].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Novel insight into ferroptosis-related genes, molecular subtypes, and immune characteristics in intracranial aneurysms.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Article
  14. Roles of Ferroptosis in Cardiovascular Diseases.Frontiers in cardiovascular medicine · 2022
    Review
  15. Article
  16. Article
  17. Article
  18. Targeting Ferroptosis as a Novel Approach to Alleviate Aortic Dissection.International journal of biological sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Hua-Xi ZouDepartment of Cardiothoracic Surgery, The Second Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, China.
Bai-Quan QiuDepartment of Cardiothoracic Surgery, The Second Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, China.
Song-Qing LaiDepartment of Cardiothoracic Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, China.
Huang HuangDepartment of Cardiothoracic Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, China.
Xue-Liang ZhouDepartment of Cardiothoracic Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, China.
Cheng-Wu GongDepartment of Cardiothoracic Surgery, The Second Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, China.
Li-Jun WangDepartment of Cardiothoracic Surgery, The Second Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, China.
Ming-Ming YuanDepartment of Cardiothoracic Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, China.
An-Di HeDepartment of Cardiothoracic Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, China.
Ji-Chun LiuDepartment of Cardiothoracic Surgery, The Second Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, China.
Nanchang University · CNFirst Affiliated Hospital of Nanchang University · CNSecond Affiliated Hospital of Nanchang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stanford type A aortic dissection (TAAD) is one of the most dangerous vascular diseases worldwide, and the mechanisms of its development remain unclear. Further molecular pathology studies may contribute to a comprehensive understanding of TAAD and provide new insights into diagnostic markers and potential therapeutic targets. Recent studies have identified that ferroptosis, a form of cell death, may play a previously unrecognized role in influencing the development of TAAD. In this study, we explored the pathological role of ferroptosis in TAAD by performing bioinformatics analyses. Gene set enrichment analysis (GSEA) showed that the ferroptosis-related gene (FRG) set was significantly different between normal and TAAD aortic samples at an overall level (

Indexed as

Computational BiologyAlgorithmsAnimalsAortic DissectionCell LineFerroptosisGene Expression ProfilingGene Expression RegulationGene OntologyGene Regulatory NetworksHumansMuscle, Smooth, VascularMyocytes, Smooth MuscleProtein Interaction MapsRatsReproducibility of Resultsbioinformatics analysisdatabaseFerroptosiskey genesStanford type a aortic dissection

Identifiers

PMID34652258
PMCPMC8809966
OpenAlexW3206970338

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.