ArticleJournal of medicinal chemistry2021
Visualization of Receptor-Interacting Protein Kinase 1 (RIPK1) by Brain Imaging with Positron Emission Tomography.
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Article in Journal of medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Regulated necrosis at the crossroads of liver inflammation and cancer development.Nature reviews. Gastroenterology & hepatology · 2026Review
- Emerging Molecular PET Imaging for Cell Death in Neurodegenerative Diseases.Journal of medicinal chemistry · 2025Review
- The Effect of Pexidartinib on Neuropathic Pain via Influences on Microglia and Neuroinflammation in Mice.Anesthesia and analgesia · 2025Article
- Development of a PET Probe Targeting Bromodomain and Extra-Terminal Proteins for In Vitro and In Vivo Visualization.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Development of a New Positron Emission Tomography Imaging Radioligand Targeting RIPK1 in the Brain and Characterization in Alzheimer's Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- The Cross-Communication of Cuproptosis and Regulated Cell Death in Human Pathophysiology.International journal of biological sciences · 2024Review
- Evaluation of specific binding of [American journal of nuclear medicine and molecular imaging · 2024Article
- Synthesis and evaluation of a novel PET ligand, a GSK'963 analog, aiming at autoradiography and imaging of the receptor interacting protein kinase 1 in the brain.EJNMMI radiopharmacy and chemistry · 2023Article
- Copper in cancer: from limiting nutrient to therapeutic target.Frontiers in oncology · 2023Review
- Synthesis of [EJNMMI radiopharmacy and chemistry · 2022Article
- Radiosynthesis and characterization of a carbon-11 PET tracer for receptor-interacting protein kinase 1.Nuclear medicine and biologyArticle
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 2 countries.
Yu LanAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.
Ping BaiAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.ORCID 0000-0003-4587-8426
Yan LiuAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.
Sepideh AfsharGordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.
Robin StriarAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.ORCID 0000-0003-0490-478X
Anna Kathryn RattrayAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.
Tyler Nicholas MeyerAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.
Amelia G LanganAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.
Alisa M PosnerAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.
Shiqian ShenDepartment of Anesthesia, Critical Care and Pain Medicine Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129 United States.
Rudolph E TanziGenetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, Massachusetts 02129, United States.
Can ZhangGenetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, Massachusetts 02129, United States.ORCID 0000-0002-4340-5118
Changning WangAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.ORCID 0000-0002-2076-4193
Harvard University · USMassachusetts General Hospital · US
Funding
Molecular imaging of RIPK1/necroptosis as a key biomarker in Alzheimer's diseaseR61AG067916 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI WANG, CHANGNING, ZHANG, CAN MARTIN · 2020 to 2022
$2.5MGut Microbiota Influences Postoperative Cognitive Dysfunction through Indole-3-Propionic AcidR35GM128692 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI SHEN, SHIQIAN · 2018 to 2022
$2.2MCharacterizing the roles of novel soluble GSMs in AD pathology.R01AG055784 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI ZHANG, CAN MARTIN · 2018 to 2022
$2.1MGut Microbiota Underlies the Heterogeneity of Aging Brain's Susceptibility to Postoperative DeliriumRF1AG070141 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI SHEN, SHIQIAN, WANG, CHANGNING · 2021 to 2021
$1.7MDevelopment and Validation of a Clinically Relevant Animal Pain ModelR33NS116423 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI SHEN, SHIQIAN · 2021 to 2022
$777kCarbon-11 Automation Equipment for Human PET Radiotracer ProductionS10OD023517 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI HOOKER, JACOB M. · 2018 to 2018
$502kDevelopment and Validation of a Clinically Relevant Animal Pain ModelR61NS116423 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI SHEN, SHIQIAN · 2020 to 2020
$420kAging Promotes Pain Chronification through Changes in PGC-1alpha Expression and Interneuron DysfunctionR03AG067947 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI SHEN, SHIQIAN · 2020 to 2021
$336kNIA NIH HHS R01 AG055784NIA NIH HHS R03 AG067947NIA NIH HHS R61 AG067916NIA NIH HHS RF1 AG070141NIGMS NIH HHS R35 GM128692NIH HHS S10 OD023517NINDS NIH HHS R33 NS116423NINDS NIH HHS R61 NS116423
Abstract
We report the development of the first positron emission tomography (PET) radiotracer, [
Indexed as
Positron-Emission TomographyAnimalsBrainDose-Response Relationship, DrugMiceMolecular StructureProtein Kinase InhibitorsReceptor-Interacting Protein Serine-Threonine KinasesStructure-Activity RelationshipProtein Kinase InhibitorsReceptor-Interacting Protein Serine-Threonine KinasesRipk1 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.