Evidence map›Paper›PMID 34651563›Full record

ArticleEmerging microbes & infections2021

One dose of COVID-19 nanoparticle vaccine REVC-128 protects against SARS-CoV-2 challenge at two weeks post-immunization.

Maggie Gu, Jonathan L Torres, Yijia Li, Alex Van Ry, Jack Greenhouse, Shannon Wallace, Chi-I Chiang, Laurent Pessaint, Abigail M Jackson, Maciel Porto and 4 more

Open access · goldAbstract read
In one paragraph

Article in Emerging microbes & infections, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Antibody-dependent enhancement of coronaviruses.International journal of biological sciences · 2025
    Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Early human B cell signatures of the primary antibody response to mRNA vaccination.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  8. Article
  9. Protein-Based Nanoparticle Vaccines for SARS-CoV-2.International journal of molecular sciences · 2021
    Review
  10. Article
  11. Article
  12. Article
  13. Unraveling the publication trends in inhalable nano-systems.Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology · 2021
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 4 countries.

Maggie GuReVacc Scientific, Frederick, MD, USA.
Jonathan L TorresDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Yijia LiReVacc Biotech, Frederick, MD, USA.
Alex Van RyBioqual, Rockville, MD, USA.
Jack GreenhouseBioqual, Rockville, MD, USA.
Shannon WallaceExperimental Pathology Laboratories, Sterling, VA, USA.
Chi-I ChiangInstitute for Bioscience and Biotechnology Research, Rockville, MD, USA.
Laurent PessaintBioqual, Rockville, MD, USA.
Abigail M JacksonDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.ORCID 0000-0001-9749-9431
Maciel PortoBioqual, Rockville, MD, USA.
Swagata KarBioqual, Rockville, MD, USA.
Yuxing LiInstitute for Bioscience and Biotechnology Research, Rockville, MD, USA.
Andrew B WardDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Yimeng WangReVacc Scientific, Frederick, MD, USA.ORCID 0000-0003-0790-1277
Bioqual · USScripps Research Institute · USResearch Institute for Bioscience and Biotechnology · NPUniversity of Maryland, Baltimore · USExperimental Pathology Laboratories · USREVA University · IN

Funding

VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Maile Ann Young Karris · 1994 to 2026
$78.4M
High-resolution definition of B cell responses to HIV Env for immunogen designR01AI102766 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI LI, YUXING · 2013 to 2024
$6.6M
Next Generation Broadly Neutralizing Antibodies to Clear HIV-1 ReservoirR01AI136756 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI LI, QINGSHENG, LI, YUXING · 2019 to 2023
$3.9M
Evolution of anti-filovirus B cell responses and mechanisms of protectionR01AI126587 · NIAID · INTEGRATED BIOTHERAPEUTICS, INC. · PI AMAN, M JAVAD, LI, YUXING · 2017 to 2021
$3.7M
Anti-flavivirus B cell response analysis to aid vaccine designR01AI175439 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Yuxing Li · 2023 to 2026
$3.1M
Monoclonal antibodies targeting novel sites of vulnerability in marburg virus glycoproteinR41AI147929 · NIAID · INTEGRATED BIOTHERAPEUTICS, INC. · PI AMAN, M JAVAD, LI, YUXING · 2019 to 2020
$600k
NIAID NIH HHS P30 AI036214NIAID NIH HHS R01 AI102766NIAID NIH HHS R01 AI126587NIAID NIH HHS R01 AI136756NIAID NIH HHS R01 AI175439NIAID NIH HHS R41 AI147929
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

SARS-CoV-2AnimalsAntibodies, NeutralizingAntibodies, ViralAntibody FormationCOVID-19COVID-19 VaccinesCricetinaeHumansImmunizationImmunization ScheduleImmunogenicity, VaccineMesocricetusMiceNanoparticlesSpike Glycoprotein, CoronavirusAntibodies, NeutralizingAntibodies, ViralCOVID-19 VaccinesSpike Glycoprotein, Coronavirusantibody-dependent enhancement (ADE)COVID-19 vaccinenanoparticle vaccineone-dose regimenSARS-CoV-2vaccine safetyvaccine stabilityvariants

Identifiers

PMID34651563
PMCPMC8567933
OpenAlexW3206423639

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.