ArticleBrain and behavior2021
Network-based rTMS to modulate working memory: The difficult choice of effective parameters for online interventions.
Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Outcome measures for electric field modeling in tES and TMS: A systematic review and large-scale modeling study.NeuroImage · 2023Pooled it
- Feasibility of Integrating Real-Time fMRI Neurofeedback with rTMS: Study Design, Preliminary Results, and Technical Challenges.Aperture neuro · 2026Article
- Chronometric TMS-fMRI of personalized left dorsolateral prefrontal target reveals state-dependency of subgenual anterior cingulate cortex effects.Molecular psychiatry · 2024Article
- Electric Field Modeling in Personalizing Transcranial Magnetic Stimulation Interventions.Biological psychiatry · 2024Review
- TAP: targeting and analysis pipeline for optimization and verification of coil placement in transcranial magnetic stimulation.Journal of neural engineering · 2022Article
- Network-based rTMS to modulate working memory: The difficult choice of effective parameters for online interventions.Brain and behavior · 2021Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
backgroundOnline repetitive transcranialmagnetic stimulation (rTMS) has been shown to modulate working memory (WM) performance in a site-specific manner, with behavioral improvements due to stimulation of the dorsolateral prefrontal cortex (DLPFC), and impairment from stimulation to the lateral parietal cortex (LPC). Neurobehavioral studies have demonstrated that subprocesses of WM allowing for the maintenance and manipulation of information in the mind involve unique cortical networks. Despite promising evidence of modulatory effects of rTMS on WM, no studies have yet demonstrated distinct modulatory control of these two subprocesses. The current study therefore sought to explore this possibility through site-specific stimulation during an online task invoking both skills.
methodsTwenty-nine subjects completed a 4-day protocol, in which active or sham 5Hz rTMS was applied over the DLPFC and LPC in separate blocks of trials while participants performed tasks that required either maintenance alone, or both maintenance and manipulation (alphabetization) of information. Stimulation targets were defined individually based on fMRI activation and structural network properties. Stimulation amplitude was adjusted using electric field modeling to equate induced current in the target region across participants.
resultsDespite the use of advanced techniques, no significant differences or interactions between active and sham stimulation were found. Exploratory analyses testing stimulation amplitude, fMRI activation, and modal controllability showed nonsignificant but interesting trends with rTMS effects.
conclusionWhile this study did not reveal any significant behavioral changes in WM, the results may point to parameters that contribute to positive effects, such as stimulation amplitude and functional activation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.