Evidence map›Paper›PMID 34651456›Full record

ReviewWiley interdisciplinary reviews. RNA2022

Non-coding RNAs in malaria infection.

Valeria Lodde, Matteo Floris, Maria Rosaria Muroni, Francesco Cucca, Maria Laura Idda

Open access · hybridAbstract readReview
In one paragraph

Review in Wiley interdisciplinary reviews. RNA, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. A Potential Regulatory Network of Selected Human Erythrocytic miRNAs withMicroRNA (Shariqah, United Arab Emirates) · 2025
    Article
  8. Review
  9. Identification of miRNA Associated withInternational journal of molecular sciences · 2023
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Non-coding RNAs in malaria infection.Wiley interdisciplinary reviews. RNA · 2022
    Review
  15. MiRNA: Biological Regulator in Host-Parasite Interaction during Malaria Infection.International journal of environmental research and public health · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Valeria LoddeDepartment of Biomedical Sciences, University of Sassari, Sassari, Italy.ORCID 0000-0001-6904-1431
Matteo FlorisDepartment of Biomedical Sciences, University of Sassari, Sassari, Italy.ORCID 0000-0003-4385-9336
Maria Rosaria MuroniDepartment of Medical, Surgical, and Experimental Sciences, University of Sassari, Sassari, Italy.
Francesco CuccaDepartment of Biomedical Sciences, University of Sassari, Sassari, Italy.
Maria Laura IddaInstitute for Genetic and Biomedical Research (IRGB), National Research Council (CNR), Sassari, Italy.ORCID 0000-0001-5243-8977
University of Sassari · ITInstitute of Genetic and Biomedical Research · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malaria is one of the most severe infectious diseases affecting humans and it is caused by protozoan pathogens of the species Plasmodium (spp.). The malaria parasite Plasmodium is characterized by a complex, multistage life cycle that requires tight gene regulation which allows for host invasion and defense against host immune responses. Unfortunately, the mechanisms regulating gene expression during Plasmodium infection remain largely elusive, though several lines of evidence implicate a major involvement of non-coding RNAs (ncRNAs). The ncRNAs have been found to play a key role in regulating transcriptional and post-transcriptional events in a broad range of organisms including Plasmodium. In Plasmodium ncRNAs have been shown to regulate key events in the multistage life cycle and virulence ability. Here we review recent progress involving ncRNAs (microRNAs, long non-coding RNAs, and circular RNAs) and their role as regulators of gene expression during Plasmodium infection in human hosts with focus on the possibility of using these molecules as biomarkers for monitoring disease status. We also discuss the surprising function of ncRNAs in mediating the complex interplay between parasite and human host and future perspectives of the field. This article is categorized under: RNA in Disease and Development > RNA in Disease.

Indexed as

MalariaMicroRNAsRNA, Long NoncodingGene Expression RegulationHumansRNA, UntranslatedMicroRNAsRNA, Long NoncodingRNA, UntranslatedlncRNAmalariamiRNAncRNAPlasmodium

Identifiers

PMID34651456
PMCPMC9286032
OpenAlexW3205744889

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.