ArticlePain practice : the official journal of World Institute of Pain2022
Adaptive body awareness predicts fewer central sensitization-related symptoms and explains relationship between central sensitization-related symptoms and pain intensity: A cross-sectional study among individuals with chronic pain.
Article in Pain practice : the official journal of World Institute of Pain, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06958263 (Factors Associated With Sensitization in Patients With Chronic Low Back Pain), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Factors Associated With Sensitization in Patients With Chronic Low Back Pain
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diminished Interoceptive Accuracy in Attention-Deficit/Hyperactivity Disorder: A Systematic Review.Psychophysiology · 2025Pooled it
- The relationship between neck and body awareness, pain, and proprioception with central sensitization in patients with chronic nonspecific neck pain.BMC musculoskeletal disorders · 2026Trial
- Bridging fibrosis and function: an integrated mechanistic and therapeutic framework for Peyronie's disease and related erectile dysfunction.Sexual medicine · 2026Review
- Multidimensional Recovery Trajectories Throughout Breast Cancer Treatment and Survivorship: A Prospective Longitudinal Study.Current oncology (Toronto, Ont.) · 2026Article
- Does Interoceptive Sensibility Mediate the Relationship Between Emotional Distress and Pain Severity? A Cross-Sectional Study in Chronic Pain and Pain-Free Individuals.European journal of pain (London, England) · 2026Article
- Interoceptive and metacognitive contributors to fatigue in multiple sclerosis: network and mediation analyses.Acta neurologica Belgica · 2026Article
- Timing of depressive episode onset relative to chronic pain reveals distinct patterns of affective and multisite pain.Frontiers in psychiatry · 2026Article
- Pain, Emotions, Interoception, and Bodily Sensations in Patients With Endometriosis.European journal of pain (London, England) · 2025Article
- BODY AWARENESS, STRESS AND SYMPTOMS IN AUTONOMIC DYSFUNCTION IN PATIENTS WITH CHRONIC PAIN: AN EXPLORATIVE STUDY.Journal of rehabilitation medicine. Clinical communications · 2024Article
- A Prognostic Model Incorporating Relevant Peripheral Blood Inflammation Indicator to Predict Postherpetic Neuralgia in Patients with Acute Herpes Zoster.Journal of pain research · 2024Article
- Interoceptive Awareness Mediates Effects of Sleep Disturbance on Pain Outcomes in Chronic Pain Patients.Integrative medicine reports · 2024Article
- CENTRAL SENSITIZATION IN PATIENTS WITH CHRONIC MUSCULOSKELETAL PAIN.Acta clinica Croatica · 2023Review
- Participant Perspectives on Community Qigong for People with Multiple Sclerosis.Integrative medicine reports · 2023Article
- The cross-cultural adaptation, validity, and reliability of the Spanish version of the Fremantle Back Awareness Questionnaire.Frontiers in psychology · 2023Article
- Yoga and pain: A mind-body complex system.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- A comparison of health-related factors between patients diagnosed with ME/CFS and patients with a related symptom picture but no ME/CFS diagnosis: a cross-sectional exploratory study.Journal of translational medicine · 2022Article
- Altered Interoceptive Sensibility in Adults With Chronic Tic Disorder.Frontiers in psychiatry · 2022Article
- Patient Outcomes Improve in a Pragmatic Implementation Pilot Study of Mindful Awareness in Body-Oriented Therapy (MABT) for Chronic Pain.Global advances in integrative medicine and healthArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundCentral sensitization (CS), defined as the amplification of neural signaling within the CNS that elicits pain hypersensitivity, is thought be a characteristic of several chronic pain conditions. Maladaptive body awareness is thought to contribute and maintain CS. Less is known about the relationship between CS and adaptive body awareness. PURPOSE: This cross-sectional study investigated relationships among self-reported adaptive body awareness (Multidimensional Interoceptive Awareness Scale-2; MAIA-2), CS-related symptoms (Central Sensitization Inventory; CSI), and pain intensity and further delineate potential direct and indirect links among these constructs.
methodsOnline surveys were administered to 280 individuals with chronic pain reporting elevated CSI scores. Strategic sampling targeted respondents to reflect the 2010 census. Pearson's correlations characterized overall relationship between variables. Multiple regression analyses investigated potential direct links. A path analysis assessed mediational effects of CS-related symptoms on the relationship between adaptive body awareness and pain intensity.
resultsCSI demonstrated strong, inverse correlations with some MAIA-2 subscales, but positive correlations with others. Higher CSI scores predicted greater pain intensity (b = 0.049, p ≤ 0.001). Two MAIA-2 subscales, Not-Distracting (b = -0.56, p ≤ 0.001) and Not-Worrying (b = -1.17, p ≤ 0.001) were unique predictors of lower CSI. Not-Distracting (b = -0.05, p = 0.003) and Not-Worrying (b = -0.06, p = 0.007) uniquely predicted lower pain intensity. CSI completely mediated the relationship between adaptive body awareness and pain intensity [point estimate = -0.04; 95% bootstrap confident intervals (CI) = -0.05 to -0.02].
conclusionsFindings also support future research to explore causal relationships of variables. Findings suggest that frequency of attention to bodily sensations is distinct from cognitive-affective appraisal of bodily sensation, and the two distinct higher order processes may have divergent influences on perceived pain and CS-related symptoms. Results also support future research to explore causal relationships of variables.
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