ArticleThe New phytologist2022
A CLE-BAM-CIK signalling module controls root protophloem differentiation in Arabidopsis.
Article in The New phytologist, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Peptide hormones in shaping root system architecture and environmental adaptation: Current advances and translational perspectives.Plant communications · 2026Review
- A CLE11b-CLE16 Signaling Relay Mediates Root-Shoot-Root Crosstalk for Drought Adaptation in Common Bean.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Plant cell surface receptors.The Plant journal : for cell and molecular biology · 2026Review
- Peptide signaling at the intersection of growth, nutrient sensing, and stress responses.The Plant journal : for cell and molecular biology · 2026Review
- Ubiquitination of BAM1 attenuates CLE peptide-mediated signaling in the root apical meristem.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- CLE pathways in plant development: recent advances and future perspectives.Journal of experimental botany · 2025Review
- Specificity of brassinosteroid perception and its integration at signaling crossroads in vascular development.The Plant journal : for cell and molecular biology · 2025Review
- Decoding small peptides: Regulators of plant growth and stress resilience.Journal of integrative plant biology · 2025Review
- Peptide hormones in plants.Molecular horticulture · 2025Review
- LRR-RLK subfamily II of coreceptors: emerging, non-canonical and canonical roles in plant antiviral immunity and development.Frontiers in plant science · 2025Review
- Physiological, transcriptomic, and genomic analysis unravels the response of Tatary buckwheat root to high ammonium stress.Frontiers in plant science · 2025Article
- Functional Analysis ofInternational journal of molecular sciences · 2024Article
- Antagonistic CLE peptide pathways shape root meristem tissue patterning.Nature plants · 2024Article
- A major role of class III HD-ZIPs in promoting sugar beet cyst nematode parasitism in Arabidopsis.PLoS pathogens · 2024Article
- CLAVATA signaling in plant-environment interactions.Plant physiology · 2024Review
- A cell-wall-modifying gene-dependent CLE26 peptide signaling confers drought resistance inPNAS nexus · 2024Article
- Chitosan induced cold tolerance inFrontiers in plant science · 2024Article
- Rapid Identification of Peptide-Receptor-Coreceptor Complexes in Protoplasts.Methods in molecular biology (Clifton, N.J.) · 2024Article
- How to explore what is hidden? A review of techniques for vascular tissue expression profile analysis.Plant methods · 2023Review
- A network of CLAVATA receptors buffers auxin-dependent meristem maintenance.Nature plants · 2023Article
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13 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Exogenous application of CLAVATA3 (CLV3)/EMBRYO SURROUNDING REGION (CLE) peptides suppresses protophloem differentiation and leads to the consumption of the proximal root meristem. However, the exact CLE peptides and the corresponding receptor complex regulating protophloem differentiation have not yet been clarified. Through expression pattern and phylogenetic analyses, CLE25/26/45 were identified as candidate peptides. Further genetic analyses, physiological assays and specific protophloem marker observations indicated that CLE25/26/45, BARELY ANY MERISTEM1/3 (BAM1/3) and CLV3 INSENSITIVE KINASEs (CIKs) are involved in regulating protophloem differentiation. The cle25 26 45 and cik2 3 4 5 6 mutation can greatly rescue the root defects of brevis radix (brx) and octopus (ops) mutants. The protophloem differentiation and proximal root meristem consumption of clv1 bam1 3 and cik2 3 4 5 6 were insensitive to CLE25/26/45 treatments. cle25 26 45, clv1 bam1 3 and cik2 3 4 5 6 displayed similar premature protophloem. In addition, CLE25/26/45 induced the interactions between BAMs and CIKs in vivo. Furthermore, CLE25/26/45 enhanced the phosphorylation levels of CIKs, which were greatly impaired in clv1 bam1 3 mutant. Our work clarifies that the CLE25/26/45-BAM1/3-CIK2/3/4/5/6 signalling module genetically acts downstream of BRX and OPS to suppress protophloem differentiation.
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