Evidence map›Paper›PMID 34651217›Full record

ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2022

Clinical outcome from hematopoietic cell transplant patients with bloodstream infection caused by carbapenem-resistant P. aeruginosa and the impact of antimicrobial combination in vitro.

Jessica Fernandes Ramos, Gleice Leite, Roberta Cristina Ruedas Martins, Camila Rizek, Sabri Saeed Al Sanabani, Flavia Rossi, Thais Guimarães, Anna Sara Levin, Vanderson Rocha, Silvia Figueiredo Costa

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Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Jessica Fernandes RamosDepartment of Infectious Diseases of Faculdade de Medicina, University of Sao Paulo, São Paulo, Brazil.
Gleice LeiteLaboratory of Medical Investigation - LIM 49 - Medical Tropical Institute, University of Sao Paulo, São Paulo, Brazil. gleice.c.leite@gmail.com.
Roberta Cristina Ruedas MartinsLaboratory of Medical Investigation - LIM 49 - Medical Tropical Institute, University of Sao Paulo, São Paulo, Brazil.
Camila RizekLaboratory of Medical Investigation - LIM 49 - Medical Tropical Institute, University of Sao Paulo, São Paulo, Brazil.
Sabri Saeed Al SanabaniLaboratory of Medical Investigation - LIM 52 - Medical Tropical Institute, University of Sao Paulo, São Paulo, Brazil.
Flavia RossiLaboratory of Clinical Microbiology of Hospital das Clínicas, Faculdade de Medicina, University of Sao Paulo, São Paulo, Brazil.
Thais GuimarãesDepartment of Infectious Diseases of Faculdade de Medicina, University of Sao Paulo, São Paulo, Brazil.
Anna Sara LevinDepartment of Infectious Diseases of Faculdade de Medicina, University of Sao Paulo, São Paulo, Brazil.
Vanderson RochaDepartment of Haematology, Hemotherapy and Cellular Therapy of Faculdade de Medicina, University of Sao Paulo, São Paulo, Brazil.
Silvia Figueiredo CostaDepartment of Infectious Diseases of Faculdade de Medicina, University of Sao Paulo, São Paulo, Brazil.
Universidade de São Paulo · BRHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bloodstream infection (BSI) caused by carbapenem-resistant P. aeruginosa (CRPA) has high mortality in hematopoietic stem cell transplant (HSCT) recipients. We performed MIC, checkerboard, time-kill assay, PFGE, PCR, and whole genome sequence and described the clinical outcome through Epi Info comparing the antimicrobial combination in vitro. Mortality was higher in BSI caused by CRPA carrying the lasB virulence gene. The isolates were 97% resistant to meropenem displaying synergistic effect to 57% in combination with colistin. Seventy-three percent of the isolates harbored bla

Indexed as

Hematopoietic Stem Cell TransplantationAdolescentAdultAnti-Bacterial AgentsBrazilCarbapenem-Resistant EnterobacteriaceaeCarbapenemsColistinFemaleHumansMaleMeropenemMicrobial Sensitivity TestsMiddle AgedPseudomonas aeruginosaPseudomonas InfectionsAnti-Bacterial AgentsCarbapenemsColistinMeropenemBloodstream infectionCarbapenem-resistant Pseudomonas aeruginosaMultidrug resistanceStem cell transplantSynergismVirulence

Identifiers

PMID34651217
OpenAlexW3207451619

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.