Evidence map›Paper›PMID 34651137›Full record

ArticleCritical care explorations2021

A Pilot Double-Blind Placebo-Controlled Randomized Clinical Trial to Investigate the Effects of Early Enteral Nutrients in Sepsis.

Faraaz Ali Shah, Georgios D Kitsios, Sachin Yende, Daniel G Dunlap, Denise Scholl, Byron Chuan, Nameer Al-Yousif, Yingze Zhang, Seyed Mehdi Nouraie, Alison Morris and 3 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care explorations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03454087 (Study of Early Enteral Dextrose in Sepsis), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03454087 nacompletednot on this map

Study of Early Enteral Dextrose in Sepsis

TypeinterventionalSponsorUniversity of PittsburghRan2018 to 2020Enrolled58ConditionsSepsisArmsEnteral Dextrose Infusion, Free Water Infusion
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Faraaz Ali Shah
Georgios D KitsiosDivision of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.
Sachin YendeVA Pittsburgh Healthcare System, Department of Critical Care Medicine, Pittsburgh, PA.
Daniel G DunlapDivision of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.
Denise SchollVA Pittsburgh Healthcare System, Department of Critical Care Medicine, Pittsburgh, PA.
Byron ChuanDivision of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.
Nameer Al-YousifDepartment of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.
Yingze ZhangDivision of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.
Seyed Mehdi NouraieDivision of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.
Alison MorrisDivision of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.
David T HuangDepartment of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.
Christopher P O'DonnellDivision of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.
Bryan J McVerryDivision of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.
University of Pittsburgh · US

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
Regulation of Cardiolin Byosynthesis in Epithelial InjuryP01HL114453 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MALLAMPALLI, RAMA K · 2014 to 2023
$21.3M
Microbiome-based diagnosis of pneumonia in the acute respiratory distress syndromeK23HL139987 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KITSIOS, GEORGIOS · 2018 to 2022
$806k
Metabolic Effects of Early Nutritional Support in Sepsis: A Translational InvestigationK23GM122069 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHAH, FARAAZ ALI · 2016 to 2020
$764k
NCATS NIH HHS UL1 TR000005NHLBI NIH HHS K23 HL139987NHLBI NIH HHS P01 HL114453NIGMS NIH HHS K23 GM122069
6 · The paper itself

Abstract

Preclinical studies from our laboratory demonstrated therapeutic effects of enteral dextrose administration in the acute phase of sepsis, mediated by the intestine-derived incretin hormone glucose-dependent insulinotropic peptide. The current study investigated the effects of an early enteral dextrose infusion on systemic inflammation and glucose metabolism in critically ill septic patients.

designSingle-center, double-blind, placebo-controlled randomized pilot clinical trial (NCT03454087).

settingTertiary-care medical center in Pittsburgh, PA. PATIENTS: Critically ill adult patients within 48 hours of sepsis diagnosis and with established enteral access.

interventionsParticipants were randomized 1:1 to receive a continuous water (placebo) or enteral dextrose infusion (50% dextrose; 0.5 g/mL) at 10 mL per hour for 24 hours. MEASUREMENTS AND MAIN

resultsWe randomized 58 participants between June 2018 and January 2020 (placebo:

conclusionsEarly infusion of low-level enteral dextrose in critically ill septic patients increased circulating levels of insulin and the incretin hormone glucose-dependent insulinotropic peptide without decreasing systemic inflammation.

Indexed as

dextroseenteral nutritionincretinsinflammationsepsis

Identifiers

PMID34651137
PMCPMC8505333
OpenAlexW3206031588

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.