Evidence map›Paper›PMID 34651098›Full record

ArticleAllergologie select2021

Guideline on management of suspected adverse reactions to ingested histamine: Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the Society for Pediatric Allergology and Environmental Medicine (GPA), the Medical Association of German Allergologists (AeDA) as well as the Swiss Society for Allergology and Immunology (SGAI) and the Austrian Society for Allergology and Immunology (ÖGAI).

Imke Reese, Barbara Ballmer-Weber, Kirsten Beyer, Sabine Dölle-Bierke, Jörg Kleine-Tebbe, Ludger Klimek, Sonja Lämmel, Ute Lepp, Joachim Saloga, Christiane Schäfer and 5 more

Open access · greenAbstract read
In one paragraph

Article in Allergologie select, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 31 citations in OpenAlex.

  1. Trial
  2. Screening and Characterization ofFoods (Basel, Switzerland) · 2026
    Article
  3. Online and Mobile Application Diet Information for Food Chemical Intolerances: An Evaluation of the Content, Quality and Health Literacy Demand.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026
    Article
  4. Review
  5. Article
  6. A Diamine Oxidase fromFoods (Basel, Switzerland) · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. [Principles of allergy diagnostics].Zeitschrift fur Rheumatologie · 2023
    Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Imke ReeseNutrition Therapy, Munich, Germany.
Barbara Ballmer-WeberClinic for Dermatology and Allergology, Cantonal Hospital St. Gallen and Department of Dermatology, University Hospital Zurich, Switzerland.
Kirsten BeyerClinic for Pediatrics with focus on Pneumology and Immunology, Charité-Universitätsmedizin - Campus Virchow-Klinikum, Berlin.
Sabine Dölle-BierkeAllergology and Immunology, Department of Dermatology, Venereology and Allergology, Charité-Universitätsmedizin Berlin.
Jörg Kleine-TebbeAllergy and Asthma Center Westend, Berlin.
Ludger KlimekCenter for Rhinology and Allergology, Wiesbaden.
Sonja LämmelGerman Allergy and Asthma Association (DAAB), Mönchengladbach.
Ute LeppPractice for Pulmonary Medicine and Allergology, Stade.
Joachim SalogaDepartment of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz.
Christiane SchäferNutrition Therapy, Schwarzenbek.
Zsolt SzepfalusiDepartment of Pediatrics, Division of Pediatric Pulmonology, Allergology and Endocrinology, Comprehensive Center Pediatrics, Medical University of Vienna, Vienna, Austria.
Regina TreudlerDepartment of Dermatology, Venereology and Allergology, Leipzig University Medical Center.
Thomas WerfelDepartment of Dermatology and Allergy, Hannover Medical School, and.
Torsten ZuberbierComprehensive Allergy Centre Charité, Department of Dermatology, Venereology and Allergology, Charité-Universitätsmedizin Berlin, Germany.
Margitta WormAllergology and Immunology, Department of Dermatology, Venereology and Allergology, Charité-Universitätsmedizin Berlin.
Zentrum für Rhinologie und Allergologie · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adverse reactions to food or food ingredients are more often perceived than objectively verifiable. However, reliable laboratory tests are often lacking. As a result, people with perceived adverse reactions to food often follow extensive elimination diets for years and unnecessarily restrict their diet, as in the case of the frequently suspected histamine intolerance. In this condition, laboratory parameters such as the determination of diamine oxidase in serum have been shown to be inconclusive. The lack of symptom reproducibility calls into question the clinical picture of adverse reactions to ingested histamine. In order to approach persons with perceived histamine intolerance and to support them in moving from blanket restrictions, which are often unnecessarily strict, to effective personalized therapeutic strategies, the present guideline of the Working Group on Food Allergy of the German Society of Allergology and Clinical Immunology (DGAKI) in cooperation with the Medical Association of German Allergists (AeDA), the Pediatric Allergology and Environmental Medicine (GPA) as well as the Swiss Society of Allergology and Immunology (SGAI) and the Austrian Society of Allergology and Immunology (ÖGAI) recommends a practicable diagnostic and therapeutic approach.

Indexed as

adverse reaction to fooddiamine oxidasediet modificationhistamine intolerancerestrictive diet

Identifiers

PMID34651098
PMCPMC8511827
OpenAlexW3204473209

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.