Evidence map›Paper›PMID 34651041›Full record

ArticleERJ open research2021

The angiostatic peptide endostatin enhances mortality risk prediction in pulmonary arterial hypertension.

Catherine E Simpson, Megan Griffiths, Jun Yang, Melanie K Nies, R Dhananjay Vaidya, Stephanie Brandal, Lisa J Martin, Michael W Pauciulo, Katie A Lutz, Anna W Coleman and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. ERJ open research · 2022
    Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Catherine E SimpsonDept of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-2388-5660
Megan GriffithsDept of Pediatrics, Division of Pediatric Cardiology, Johns Hopkins University, Baltimore, MD, USA.
Jun YangDept of Pediatrics, Division of Pediatric Cardiology, Johns Hopkins University, Baltimore, MD, USA.
Melanie K NiesDept of Pediatrics, Division of Pediatric Cardiology, Johns Hopkins University, Baltimore, MD, USA.
R Dhananjay VaidyaDept of Medicine, Division of General Internal Medicine, Johns Hopkins University, Baltimore, MD, USA.
Stephanie BrandalDept of Pediatrics, Division of Pediatric Cardiology, Johns Hopkins University, Baltimore, MD, USA.
Lisa J MartinDept of Pediatrics, Division of Human Genetics, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Michael W PauciuloDept of Pediatrics, Division of Human Genetics, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Katie A LutzDept of Pediatrics, Division of Human Genetics, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Anna W ColemanDept of Pediatrics, Division of Human Genetics, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Eric D AustinDept of Pediatrics, Division of Allergy, Immunology, and Pulmonary Medicine, Vanderbilt University, Nashville, TN, USA.ORCID https://orcid.org/0000-0002-1709-9022
D Dunbar IvyDept of Pediatric Cardiology, Children's Hospital Colorado, Denver, CO, USA.
William C NicholsDept of Pediatrics, Division of Human Genetics, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Allen D EverettDept of Pediatrics, Division of Pediatric Cardiology, Johns Hopkins University, Baltimore, MD, USA.
Paul M HassounDept of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA.
Rachel L DamicoDept of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA.
Johns Hopkins University · USCincinnati Children's Hospital Medical Center · USChildren's Hospital Colorado · USVanderbilt University · US

Funding

Pediatric Scientist Development Program (PSDP) [K12]K12HD000850 · NICHD · YALE UNIVERSITY · PI Sallie R. Permar · 1987 to 2026
$44.1M
National Biological Sample and Data Repository for PAHR24HL105333 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI NICHOLS, WILLIAM C · 2012 to 2016
$10.1M
Clinical and mechanistic role of HDGF in pulmonary hypertensionR01HL135114 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI EVERETT, ALLEN D · 2017 to 2020
$2.9M
Role of IGF axis in pulmonary hypertensionR01HL150070 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI EVERETT, ALLEN D, YANG, JUN · 2020 to 2023
$2.8M
Functional Impact of Col18a1/Endostatin Variants in PAHR01HL132153 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI DAMICO, RACHEL L, HASSOUN, PAUL M. · 2017 to 2020
$2.5M
The role of xanthine oxidoreductase activity and altered metabolism in scleroderma-associated pulmonary arterial hypertensionK23HL153781 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SIMPSON, CATHERINE · 2020 to 2024
$883k
NHLBI NIH HHS K23 HL153781NHLBI NIH HHS R01 HL132153NHLBI NIH HHS R01 HL135114NHLBI NIH HHS R01 HL150070NHLBI NIH HHS R24 HL105333NICHD NIH HHS K12 HD000850
6 · The paper itself

Abstract

Currently available noninvasive markers for assessing disease severity and mortality risk in pulmonary arterial hypertension (PAH) are unrelated to fundamental disease biology. Endostatin, an angiostatic peptide known to inhibit pulmonary artery endothelial cell migration, proliferation and survival

Identifiers

PMID34651041
PMCPMC8503279
OpenAlexW3198907422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.