Evidence map›Paper›PMID 34651002›Full record

ReviewFrontiers in medicine2021

Clinical Applications of Liquid Biopsy in Gastric Cancer.

Mihaela Chivu-Economescu, Laura Necula, Lilia Matei, Denisa Dragu, Coralia Bleotu, Carmen C Diaconu

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Collagen Family as Promising Biomarkers and Therapeutic Targets in Cancer.International journal of molecular sciences · 2022
    Review
  11. Article
  12. Review
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Mihaela Chivu-EconomescuDepartment of Cellular and Molecular Pathology, Stefan S. Nicolau Institute of Virology, Bucharest, Romania.
Laura NeculaDepartment of Cellular and Molecular Pathology, Stefan S. Nicolau Institute of Virology, Bucharest, Romania.
Lilia MateiDepartment of Cellular and Molecular Pathology, Stefan S. Nicolau Institute of Virology, Bucharest, Romania.
Denisa DraguDepartment of Cellular and Molecular Pathology, Stefan S. Nicolau Institute of Virology, Bucharest, Romania.
Coralia BleotuDepartment of Cellular and Molecular Pathology, Stefan S. Nicolau Institute of Virology, Bucharest, Romania.
Carmen C DiaconuDepartment of Cellular and Molecular Pathology, Stefan S. Nicolau Institute of Virology, Bucharest, Romania.
Titu Maiorescu University · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liquid biopsy represents an exciting new area in the field of cancer diagnosis and management, offering a less invasive and more convenient approach to obtain a time-point image of the tumor burden and its genomic profile. Samples collected from several body fluids, mostly blood, can be used to gain access to circulating tumor cells and DNA, non-coding RNAs, microRNAs, and exosomes, at any moment, offering a dynamic picture of the tumor. For patients with GC, the use of blood-based biopsies may be particularly beneficial since tissue biopsies are difficult to obtain and cause real distress to the patient. With advantages such as repeatability and minimal invasion, it is no wonder that the field of liquid biopsy has received tremendous attention. However, the abundance of studies, involving a wide range of assays with different principles, prevented for the moment the reproducibility of the results and therefore the translation into the clinic of liquid biopsy. In this review, we present the latest technical development and data on circulating biomarkers available through liquid biopsy in gastric cancer with an emphasis on their clinical utility in areas such as cancer screening, prognostic stratification, and therapeutic management.

Indexed as

circulating non-coding RNAs (ncRNA)circulating tumor cells (CTCs)circulating tumor DNA (ctDNA)exosomesgastric cancerliquid biopsyprognosisscreening

Identifiers

PMID34651002
PMCPMC8505538
OpenAlexW3204827599

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.