Evidence map›Paper›PMID 34650977›Full record

ArticleFrontiers in cell and developmental biology2021

Direct Current Stimulation Disrupts Endothelial Glycocalyx and Tight Junctions of the Blood-Brain Barrier

Yifan Xia, Yunfei Li, Wasem Khalid, Marom Bikson, Bingmei M Fu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. The Glycocalyx: The Importance of Sugar Coating the Blood-Brain Barrier.International journal of molecular sciences · 2024
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yifan XiaDepartment of Biomedical Engineering, The City College of the City University of New York, New York, NY, United States.
Yunfei LiDepartment of Biomedical Engineering, The City College of the City University of New York, New York, NY, United States.
Wasem KhalidDepartment of Biomedical Engineering, The City College of the City University of New York, New York, NY, United States.
Marom BiksonDepartment of Biomedical Engineering, The City College of the City University of New York, New York, NY, United States.
Bingmei M FuDepartment of Biomedical Engineering, The City College of the City University of New York, New York, NY, United States.
City College of New York · US

Funding

Integrated Microphysiological System of Cerebral Organoid and Blood Vessel for Disease Modeling and Neuropsychiatric Drug screeningUH3TR002151 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LEONG, KAM W · 2020 to 2022
$3.6M
Integrated Microphysiological System of Cerebral Organoid and Blood Vessel for Disease Modeling and Neuropsychiatric Drug screeningUG3TR002151 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LEONG, KAM W · 2018 to 2019
$2.6M
The coupled vascular hypothesis for transcranial direct current stimulation (tDCS)R01NS101362 · NINDS · CITY COLLEGE OF NEW YORK · PI BIKSON, MAROM · 2017 to 2021
$1.7M
NCATS NIH HHS UG3 TR002151NCATS NIH HHS UH3 TR002151NINDS NIH HHS R01 NS101362
6 · The paper itself

Abstract

Transcranial direct current stimulation (tDCS) is a non-invasive physical therapy to treat many psychiatric disorders and to enhance memory and cognition in healthy individuals. Our recent studies showed that tDCS with the proper dosage and duration can transiently enhance the permeability (P) of the blood-brain barrier (BBB) in rat brain to various sized solutes. Based on the

Indexed as

heparan sulfatehuman cerebral microvascular endothelial cellshyaluronic acidinhibition of endothelial nitric oxide synthase (eNOS)mouse brain microvascular endothelial cellssolute permeabilitytrans-endothelial electrical resistance (TEER)ZO-1

Identifiers

PMID34650977
PMCPMC8505730
OpenAlexW3204534630

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.