ArticleAmerican journal of translational research2021
The antiviral immune defense may be adversely influenced by weight loss through a calorie restriction program in obese women.
Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- Immune and metabolic remodeling following bariatric surgery: Implications for targeted immunotherapy (Review).International journal of molecular medicine · 2026Review
- Prognostic significance of preoperative nutritional status for heart transplantation patients.BMC cardiovascular disorders · 2024Article
- Fasting and calorie restriction modulate age-associated immunosenescence and inflammaging.Aging medicine (Milton (N.S.W)) · 2024Review
- Calorie restriction-induced leptin reduction and T-lymphocyte activation in blood and adipose tissue in men with overweight and obesity.International journal of obesity (2005) · 2024Article
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Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity and weight loss are reported to be associated with immune function. This study aimed to investigate the changes in counts of lymphocytes involved in microbial defense during weight loss in obese women.
methodsThis clinical trial involved 29 women with a body mass index (BMI) ≥ 30 kg/m
resultsAfter the weight loss, natural killer cells (CD16/56) decreased in the intervention group (P=0.014) even after adapting for all confounders. No significant changes were observed in other immune markers compared to the control group.
conclusionsCaloric restriction-induced weight loss might independently weaken the antiviral immune defense. Further clinical trials are warranted to better clarify the association between weight loss, calorie restriction, and immunity.
Indexed as
Identifiers
34650709PMC8507012W3206503106What OpenQuestion holds
Registered trials
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