Evidence map›Paper›PMID 34650659›Full record

ArticleThe Pan African medical journal2021

Assessment of thyroid function of newly diagnosed SARS-CoV-2 infected patients in Nigeria.

Chika Juliet Okwor, Ijeoma Angela Meka, Kazeem Sanjo Akinwande, Victory Fabian Edem, Vitalis Chukwuemeka Okwor

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Pan African medical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 4 pooled it
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 4 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Chika Juliet OkworDepartment of Chemical Pathology, University of Nigeria Teaching Hospital, Ituku/Ozalla, Enugu, Nigeria.
Ijeoma Angela MekaDepartment of Chemical Pathology, University of Nigeria Teaching Hospital, Ituku/Ozalla, Enugu, Nigeria.
Kazeem Sanjo AkinwandeDepartment of Chemical Pathology and Immunology, Federal Medical Centre, Abeokuta, Ogun State, Nigeria.
Victory Fabian EdemDepartment of Immunology, University of Ibadan, Oyo State, Nigeria.
Vitalis Chukwuemeka OkworDepartment of Radiation Medicine, University of Nigeria Teaching Hospital, Ituku/Ozalla Enugu, Nigeria.
University of Nigeria Teaching Hospital · NGFederal Medical Centre · NGUniversity of Ibadan · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionthe outbreak and rapid spread of the novel SARS-CoV-2, the causative agent of the coronavirus disease 2019 (COVID-19), has evolved into an unprecedented global pandemic. The infection impairs several human organs and systems, however, it is not clear how it affects thyroid function. The study therefore aimed at measuring plasma levels of thyroid hormones and Hs-CRP in COVID-19 patients and apparently healthy uninfected controls to assess the possible effect of SAR-CoV-2 infection on thyroid function.

methodsin this cross-sectional study carried out between May-August 2020, 90 consenting participants comprising 45 COVID-19 patients and 45 apparently healthy uninfected controls were recruited. Plasma FT3, FT4, TSH and Hs-CRP were measured using Enzyme Linked Immunosorbent Assay (ELISA) method. Data was analysed using SPSS version 20 and statistical significance set at p < 0.05.

resultsthe mean plasma FT3 and TSH concentrations were significantly higher in COVID-19 patients compared to controls (p < 0.001, p < 0.001 respectively). Euthyroidism was observed in all uninfected controls, whereas 35 (77.8%) COVID-19 patients were euthyroid. Sick euthyroid and subclinical hypothyroidism was observed in 7 (15.6%) and 3 (6.7%) COVID-19 patients, respectively.

conclusionthough there was a preponderance of euthyroidism among COVID-19 patients, significantly higher mean plasma levels of TSH and FT3, sick euthyroid syndrome and subclinical hypothyroidism observed among some COVID-19 patients may be indicative of disease-related thyroid function changes. Hence, there is need to pay attention to thyroid function during and after treatment of COVID-19.

Indexed as

AdultCase-Control StudiesCOVID-19Cross-Sectional StudiesEuthyroid Sick SyndromesFemaleHumansHypothyroidismMaleMiddle AgedNigeriaThyroid DiseasesThyroid HormonesYoung AdultThyroid HormonesCOVID-19thyroid functionthyroid stimulating hormonethyroxinetri-iodothyronine

Identifiers

PMID34650659
PMCPMC8490165
OpenAlexW3196731009

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.