Evidence map›Paper›PMID 34650645›Full record

ArticleExperimental and therapeutic medicine2021

Heparin alleviates LPS-induced endothelial injury by regulating the TLR4/MyD88 signaling pathway.

Wenxun Liu, Yan Li, Zhaozhao Wu, Kerong Hai, Yun Wang, Xiaohong Zhou, Qingshan Ye

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental and therapeutic medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Exploring the Regulatory Mechanism of Total Alkaloids fromInternational journal of molecular sciences · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Wenxun LiuAnesthesia Specialty, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China.
Yan LiAnesthesia Specialty, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China.
Zhaozhao WuDepartment of Anesthesiology, Northwest Minzu University, Lanzhou, Gansu 730030, P.R. China.
Kerong HaiDepartment of Anesthesiology, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan, Ningxia 750002, P.R. China.
Yun WangDepartment of Anesthesiology, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan, Ningxia 750002, P.R. China.
Xiaohong ZhouDepartment of Anesthesiology, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan, Ningxia 750002, P.R. China.
Qingshan YeDepartment of Anesthesiology, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan, Ningxia 750002, P.R. China.
The Fourth People's Hospital of Ningxia Hui Autonomous Region · CNNingxia Medical University · CNMinzu University of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heparin is a commonly used in the clinic, however, Heparin's effect on endothelial injury remains unclear. The aim of the present study was to evaluate the effects and possible mechanisms of action underlying heparin treatment in lipopolysaccharide (LPS)-induced endothelial injury

Indexed as

apoptosisendothelial injuryheparintoll-like receptor 4/myeloid differentiation primary response 88/NF-κB (p65)

Identifiers

PMID34650645
PMCPMC8506914
OpenAlexW3202364838

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.