Evidence map›Paper›PMID 34650561›Full record

ArticleFrontiers in immunology2021

Characterising the Phenotypic Diversity of Antigen-Specific Memory B Cells Before and After Vaccination.

M Christian Tjiam, Sonia Fernandez, Martyn A French

Open access · goldAbstract readComparative Study
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

M Christian TjiamSchool of Biomedical Sciences, The University of Western Australia, Crawley, WA, Australia.
Sonia FernandezDivision of Immunology, PathWest Laboratory Medicine, Nedlands, WA, Australia.
Martyn A FrenchSchool of Biomedical Sciences, The University of Western Australia, Crawley, WA, Australia.
University of Western Australia · AUPathwest Laboratory Medicine · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The diversity of B cell subsets and their contribution to vaccine-induced immunity in humans are not well elucidated but hold important implications for rational vaccine design. Prior studies demonstrate that B cell subsets distinguished by immunoglobulin (Ig) isotype expression exhibit divergent activation-induced fates. Here, the antigen-specific B cell response to tetanus toxoid (TTd) booster vaccination was examined in healthy adults, using a dual-TTd tetramer staining flow cytometry protocol. Unsupervised analyses of the data revealed that prior to vaccination, IgM-expressing CD27

Indexed as

Immunization, SecondaryCD79 AntigensDiphtheria-Tetanus VaccineHealthy VolunteersHumansImmunoglobulinsImmunologic MemoryInducible T-Cell Co-Stimulator ProteinMemory B CellsPhenotypeProgrammed Cell Death 1 ReceptorTetanus ToxinT Follicular Helper CellsTumor Necrosis Factor Receptor Superfamily, Member 7CD79 AntigensCD79B protein, humanDiphtheria-Tetanus VaccineICOS protein, humanImmunoglobulinsInducible T-Cell Co-Stimulator ProteinPDCD1 protein, humanProgrammed Cell Death 1 ReceptorTetanus ToxinTumor Necrosis Factor Receptor Superfamily, Member 7antigen-specific B cellB-cellsIgAIgDIgGIgMisotypevaccine

Identifiers

PMID34650561
PMCPMC8505969
OpenAlexW3202203622

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.