Evidence map›Paper›PMID 34650521›Full record

ArticleFrontiers in endocrinology2021

Peripheral Hybrid CB

Charles N Zawatsky, Joshua K Park, Jasmina Abdalla, George Kunos, Malliga R Iyer, Resat Cinar

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Pharmacological Evaluation of Cannabinoid Receptor Modulators Using GRABInternational journal of molecular sciences · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. The Peripheral Cannabinoid Receptor Type 1 (CBMolecules (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Charles N ZawatskySection on Fibrotic Disorders, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, United States.
Joshua K ParkLaboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, United States.
Jasmina AbdallaSection on Fibrotic Disorders, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, United States.
George KunosLaboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, United States.
Malliga R IyerLaboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, United States.
Resat CinarSection on Fibrotic Disorders, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, United States.
National Institute on Alcohol Abuse and Alcoholism · USNational Institutes of Health · US

Funding

Fibroproliferative mechanisms in organ fibrosisZIAAA000355 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI CINAR, RESAT · 2021 to 2025
$6.6M
6 · The paper itself

Abstract

Scleroderma, or systemic sclerosis, is a multi-organ connective tissue disease resulting in fibrosis of the skin, heart, and lungs with no effective treatment. Endocannabinoids acting

Indexed as

Antifibrotic AgentsFibrosisNitric Oxide Synthase Type IIReceptor, Cannabinoid, CB1Skin DiseasesAnimalsAntibiotics, AntineoplasticATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily G, Member 2BleomycinEndocannabinoidsHumansHydroxyprolineMaleMiceMice, Inbred C57BLAbcg2 protein, mouseAntibiotics, AntineoplasticAntifibrotic AgentsATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily G, Member 2BleomycinCNR1 protein, mouseEndocannabinoidsHydroxyprolineMRI-1867Nitric Oxide Synthase Type IINOS2 protein, humanPyrazolesReceptor, Cannabinoid, CB1Sulfur CompoundsATP-binding cassette transportersbleomycincannabinoid (CB) receptor 1endocannabinoidsperipheral CB1R antagonistP-gp (P-glycoprotein)polypharmacologyskin fibrosis

Identifiers

PMID34650521
PMCPMC8505776
OpenAlexW3204332334

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.