Evidence map›Paper›PMID 34650520›Full record

ArticleFrontiers in endocrinology2021

Role of Ubiquilins for Brown Adipocyte Proteostasis and Thermogenesis.

Carolin Muley, Stefan Kotschi, Alexander Bartelt

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Carolin MuleyInstitute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University, Munich, Germany.
Stefan KotschiInstitute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University, Munich, Germany.
Alexander BarteltInstitute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University, Munich, Germany.
Ludwig-Maximilians-Universität München · DEGerman Centre for Cardiovascular Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The acclimatization of brown adipose tissue (BAT) to sustained cold exposure requires an adaptive increase in proteasomal protein quality control. Ubiquilins represent a recently identified family of shuttle proteins with versatile functions in protein degradation, such as facilitating substrate targeting and proteasomal degradation. However, whether ubiquilins participate in brown adipocyte function has not been investigated so far. Here, we determine the role of ubiquilins for proteostasis and non-shivering thermogenesis in brown adipocytes. We found that

Indexed as

Adipocytes, BrownAdipose Tissue, BrownAnimalsCell LineEndoplasmic Reticulum StressMiceProteasome Endopeptidase ComplexProteostasisThermogenesisUbiquitinsUncoupling Protein 1Proteasome Endopeptidase ComplexUbiquitinsUncoupling Protein 1brown adipose tissuecold adaptationproteostasisthermogenesisubiquilinsubiquitin-proteasome-system

Identifiers

PMID34650520
PMCPMC8505974
OpenAlexW3204647726

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.