Evidence map›Paper›PMID 34650423›Full record

ArticleFrontiers in aging neuroscience2021

Increased Levels of Circulating Angiogenic Cells and Signaling Proteins in Older Adults With Cerebral Small Vessel Disease.

Arunima Kapoor, Aimée Gaubert, Anisa Marshall, Irene B Meier, Belinda Yew, Jean K Ho, Anna E Blanken, Shubir Dutt, Isabel J Sible, Yanrong Li and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 44 citations in OpenAlex.

  1. New perspectives on VEGF signalling in Alzheimer's disease.Brain pathology (Zurich, Switzerland) · 2026
    Review
  2. Article
  3. Article
  4. Low frequency BOLD oscillations,medRxiv : the preprint server for health sciences · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Arunima KapoorDepartment of Psychological Science, University of California, Irvine, Irvine, CA, United States.
Aimée GaubertInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, United States.
Anisa MarshallDepartment of Psychology, University of Southern California, Los Angeles, CA, United States.
Irene B MeierDepartment of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, United States.
Belinda YewDepartment of Psychology, University of Southern California, Los Angeles, CA, United States.
Jean K HoInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, United States.
Anna E BlankenDepartment of Psychology, University of Southern California, Los Angeles, CA, United States.
Shubir DuttDepartment of Psychology, University of Southern California, Los Angeles, CA, United States.
Isabel J SibleDepartment of Psychology, University of Southern California, Los Angeles, CA, United States.
Yanrong LiInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, United States.
Jung Yun JangInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, United States.
Adam M BrickmanDepartment of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, United States.
Kathleen RodgersCenter for Innovation in Brain Science, Department of Pharmacology, The University of Arizona, Tucson, AZ, United States.
Daniel A NationDepartment of Psychological Science, University of California, Irvine, Irvine, CA, United States.
University of California, Irvine · USUniversity of Southern California · USColumbia University · USUniversity of Arizona · US

Funding

UC Irvine Alzheimer's Disease Research Center Induced Pluripotent Stem Cell CoreP50AG016573 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI LAFERLA, FRANK M · 2000 to 2019
$37.0M
Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's DiseaseP01AG052350 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation, ARTHUR W TOGA · 2016 to 2026
$28.4M
Endothelial progenitor cells and neurovascular injury in the aging brainR01AG064228 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation · 2019 to 2026
$4.5M
Cerebrovascular resistance in cognitive aging and Alzheimer's disease riskR01AG060049 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI NATION, DANIEL A · 2020 to 2023
$2.4M
NIA NIH HHS P01 AG052350NIA NIH HHS P50 AG016573NIA NIH HHS R01 AG060049NIA NIH HHS R01 AG064228
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

agingcerebral microvascular pathologycerebral small vessel diseasedementiaendothelial progenitor cellsvascular dementiavascular endothelial growth factor

Identifiers

PMID34650423
PMCPMC8510558
OpenAlexW3201852253

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.