Evidence map›Paper›PMID 34650391›Full record

ArticleFood & nutrition research2021

Is preterm donor milk better than preterm formula for very-low-birth-weight infants?

Lingyu Fang, Meili Zhang, Lianqiang Wu, Ruiquan Wang, Bangbang Lin, Jianfeng Yao, Dongmei Chen

Abstract read
In one paragraph

Article in Food & nutrition research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Observational
  5. Balancing access to donor human milk: Rationing vs expanding use.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026
    Review
  6. Article
  7. Article
  8. Impact of Donor Human Milk in an Urban NICU Population.Children (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lingyu FangNeonatal Intensive Care Unit, Quanzhou Women and Children's Hospital, Quanzhou, Fujian, China.
Meili ZhangNeonatal Intensive Care Unit, Quanzhou Women and Children's Hospital, Quanzhou, Fujian, China.
Lianqiang WuNeonatal Intensive Care Unit, Quanzhou Women and Children's Hospital, Quanzhou, Fujian, China.
Ruiquan WangNeonatal Intensive Care Unit, Quanzhou Women and Children's Hospital, Quanzhou, Fujian, China.
Bangbang LinAdministrative Office, Quanzhou Women and Children's Hospital, Quanzhou, Fujian, China.
Jianfeng YaoReproductive Medicine Center, Quanzhou Women and Children's Hospital, Quanzhou, Fujian, China.
Dongmei ChenNeonatal Intensive Care Unit, Quanzhou Women and Children's Hospital, Quanzhou, Fujian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPreterm human milk has advantages over preterm formula (PF), but it may compromise some functions after pasteurization.

objectiveTo explore the effects of preterm donor milk (DM) on growth, feeding tolerance, and severe morbidity in very-low-birth-weight infants.

methodThis was a single-center, prospective cohort study that included 304 preterm infants weighing <1,500 g or of gestational age <32 weeks. If the mother's own milk was insufficient, the parents decided to use PF (

resultsThe daily weight gain and weekly head growth in the DM group were not different from those in the PF group (

conclusionThe study indicated that preterm DM does not affect the growth of very-low-birth-weight infants. Further, it significantly reduces feeding intolerance, helps achieve full enteral feeding early, and has protective effects against necrotizing enterocolitis and sepsis. Thus, compared with formula, preterm DM can lower the rate of infection in preterm infants and is worthy of promotion.

Indexed as

development and growthmilk banknecrotizing enterocolitissepsisvery-low-birth-weight infant

Identifiers

PMID34650391
PMCPMC8494261

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.