Evidence map›Paper›PMID 34650382›Full record

ArticleEuropean heart journal supplements : journal of the European Society of Cardiology2021

Thrombosis in pre- and post-vaccination phase of COVID-19.

Francesco Violi, Vittoria Cammisotto, Daniele Pastori, Pasquale Pignatelli

Open access · hybridAbstract read
In one paragraph

Article in European heart journal supplements : journal of the European Society of Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Francesco VioliDepartment of Clinical Internal, Anestesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Vittoria CammisottoDepartment of General Surgery and Surgical Speciality Paride Stefanini, Sapienza University of Rome, Rome, Italy.
Daniele PastoriDepartment of Clinical Internal, Anestesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Pasquale PignatelliDepartment of Clinical Internal, Anestesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Sapienza University of Rome · ITClinica Mediterranea · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute infections may be complicated by thrombosis occurring in the venous and arterial circulation. This may be observed in patients with community-acquired pneumonia (CAP) and also in patients with coronavirus 2019 (COVID-19), that is a pandemic characterized by severe acute respiratory syndrome (SARS-CoV-2) needing mechanical ventilation and intensive care unit treatment. However, the type and rate of thrombosis can vary according to the cause of pneumonia as is more frequently complicated by arterial thrombosis in CAP, while an equal incidence of venous and arterial thrombosis occurs in SARS-CoV-2. The mechanisms of disease are overall platelet-related in CAP while activation of both platelets and clotting system is implicated in the pathogenesis of thrombosis in SARS-CoV-2; this finding could imply a different therapeutic approach of the two settings. Thrombosis may also occur in subjects vaccinated against SARS-CoV-2 even if its incidence is not so high (1/100 000); this rare effect occurs more prevalently in young women, is independent from known risk factors of thrombosis, is caused by antibodies against platelet PF4 and is counteracted by treatment with immunoglobulin and glucocorticoids.

Indexed as

Community-acquired pneumoniaCOVID-19PlateletsThrombosisVaccine-induced thrombotic thrombocytopenia

Identifiers

PMID34650382
PMCPMC8503327
OpenAlexW3205391763

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.