Evidence map›Paper›PMID 34650272›Full record

ArticleNature metabolism2021

Fasting-mimicking diet prevents high-fat diet effect on cardiometabolic risk and lifespan.

Amrendra Mishra, Hamed Mirzaei, Novella Guidi, Manlio Vinciguerra, Alice Mouton, Marina Linardic, Francesca Rappa, Rosario Barone, Gerardo Navarrete, Min Wei and 9 more

Registry-linked trialOpen access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Nature metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07065955 (Effects of the Longevity Diet and the Fasting-mimicking Diet on Body Composition, Risk Factors for Age-related Diseases), which is not on this map. Cited by 47 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 2 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07065955 completednot on this map

Effects of the Longevity Diet and the Fasting-mimicking Diet on Body Composition, Risk Factors for Age-related Diseases

TypeobservationalSponsorFondazione Valter LongoRan2019 to 2024Enrolled365ConditionsOverweight, Obesity, Metabolic Syndrome, Autoimmune DiseasesArmsLongevity diet alone or in combination with fasting mimicking diet
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.

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  13. Food science & nutrition · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 3 countries.

Amrendra Mishra *Longevity Institute and Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Hamed Mirzaei *Longevity Institute and Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Novella Guidi *Longevity Institute and Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Manlio VinciguerraInternational Clinical Research Center, St Anne's University Hospital, Brno, Czech Republic.
Alice MoutonDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-0598-8789
Marina LinardicDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, USA.
Francesca RappaSection of Human Anatomy, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo, Palermo, Italy.ORCID http://orcid.org/0000-0001-6610-5268
Rosario BaroneSection of Human Anatomy, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo, Palermo, Italy.
Gerardo NavarreteLongevity Institute and Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Min WeiLongevity Institute and Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Sebastian BrandhorstLongevity Institute and Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Stefano Di BiaseLongevity Institute and Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Todd E MorganLongevity Institute and Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-9874-5080
S Ram KumarDepartment of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Peter S ContiMolecular Imaging Center, Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Matteo PellegriniDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, USA.
Michel BernierTranslational Gerontology Branch, Intramural Research Program of the National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-5948-368X
Rafael de CaboTranslational Gerontology Branch, Intramural Research Program of the National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-3354-2442
Valter D LongoLongevity Institute and Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA. vlongo@usc.edu.ORCID http://orcid.org/0000-0002-0946-7534
University of Southern California · USUniversity of California, Los Angeles · USNational Institutes of Health · USUniversity of Palermo · ITUniversity Hospital Brno · CZ

Funding

Role of the Mitochondrial Peptide Humanin in Regulating Aging and HealthspanP01AG055369 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LONGO, VALTER D. · 2018 to 2023
$12.4M
NIA NIH HHS P01 AG055369
6 · The paper itself

Abstract

Diet-induced obesity is a major risk factor for metabolic syndrome, diabetes and cardiovascular disease. Here, we show that a 5-d fasting-mimicking diet (FMD), administered every 4 weeks for a period of 2 years, ameliorates the detrimental changes caused by consumption of a high-fat, high-calorie diet (HFCD) in female mice. We demonstrate that monthly FMD cycles inhibit HFCD-mediated obesity by reducing the accumulation of visceral and subcutaneous fat without causing loss of lean body mass. FMD cycles increase cardiac vascularity and function and resistance to cardiotoxins, prevent HFCD-dependent hyperglycaemia, hypercholesterolaemia and hyperleptinaemia and ameliorate impaired glucose and insulin tolerance. The effect of monthly FMD cycles on gene expression associated with mitochondrial metabolism and biogenesis in adipocytes and the sustained ketogenesis in HFCD-fed mice indicate a role for fat cell reprogramming in obesity prevention. These effects of an FMD on adiposity and cardiac ageing could explain the protection from HFCD-dependent early mortality.

Indexed as

Diet, High-FatFastingLongevityAnimalsCardiovascular DiseasesFemaleMetabolic DiseasesMice

Identifiers

PMID34650272
OpenAlexW3206034432

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.