ArticleMolecular psychiatry2022
Acute social isolation and regrouping cause short- and long-term molecular changes in the rat medial amygdala.
Article in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- PTSD symptoms, loneliness, and amygdala volumes during pandemic social distancing associated with risk of suicidal ideation in trauma survivors with and without pre-pandemic PTSD.Journal of affective disorders reports · 2026Article
- Long-term social isolation during adolescence exacerbated cardiac dysfunction after myocardial infarction.Translational psychiatry · 2026Article
- Sex Differences in the Effects of Early Life Stressors in a Rat Model of Myofascial Low Back Pain.European journal of pain (London, England) · 2025Article
- Juvenile social isolation in Sprague Dawley rats does not have a lasting impact on social behavior in adulthood.Scientific reports · 2025Article
- Effect of the social environment on olfaction and social skills in wild-type and a mouse model of autism.Translational psychiatry · 2024Article
- COVID-19 related cognitive, structural and functional brain changes among Italian adolescents and young adults: a multimodal longitudinal case-control study.Translational psychiatry · 2024Article
- Environmental Deprivation Effects on Myelin Ultrastructure in Huntington Disease and Wildtype Mice.Molecular neurobiology · 2024Article
- Social Isolation Induces Changes in the Monoaminergic Signalling in the Rat Medial Prefrontal Cortex.Cells · 2024Article
- Shrinking the footprint of the criminal legal system through policies informed by psychology and neuroscience.Communications psychology · 2024Review
- A protocol for investigating long-term social discrimination memory: Evidence in female and male Long Evans rats.PloS one · 2024Article
- Neurosustainability.Frontiers in human neuroscience · 2024Article
- Evaluation of the Effects of Instant Cascara Beverage on the Brain-Gut Axis of Healthy Male and Female Rats.Nutrients · 2023Article
- Characterizing the mechanisms of social connection.Neuron · 2023Review
- Social interaction following prepubertal stress alters prefrontal gene expression associated with cell signalling and oligodendrocytes.Translational psychiatry · 2022Article
- Dynamic influences on the neural encoding of social valence.Nature reviews. Neuroscience · 2022Review
- Affective Neuroscience of Loneliness: Potential Mechanisms underlying the Association between Perceived Social Isolation, Health, and Well-Being.Journal of psychiatry and brain science · 2022Article
- Neurobiology of Loneliness, Isolation, and Loss: Integrating Human and Animal Perspectives.Frontiers in behavioral neuroscience · 2022Review
- COVID-19, Stress, and Brain Morphometry: Opportunities and Challenges for Linking Neuroscience, Translational Psychiatry, and Health Services Research.Biological psychiatry global open science · 2021Article
- Social determinants of health, genetic biomarkers, and cognitive function in Chinese older adults with subjective cognitive decline and mild cognitive impairment: A cross-sectional analysis.Journal of Alzheimer's disease reportsArticle
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Social isolation poses a severe mental and physiological burden on humans. Most animal models that investigate this effect are based on prolonged isolation, which does not mimic the milder conditions experienced by people in the real world. We show that in adult male rats, acute social isolation causes social memory loss. This memory loss is accompanied by significant changes in the expression of specific mRNAs and proteins in the medial amygdala, a brain structure that is crucial for social memory. These changes particularly involve the neurotrophic signaling and axon guidance pathways that are associated with neuronal network remodeling. Upon regrouping, memory returns, and most molecular changes are reversed within hours. However, the expression of some genes, especially those associated with neurodegenerative diseases remain modified for at least a day longer. These results suggest that acute social isolation and rapid resocialization, as experienced by millions during the COVID-19 pandemic, are sufficient to induce significant changes to neuronal networks, some of which may be pathological.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.