ArticleMolecular psychiatry2022
Association between parental age, brain structure, and behavioral and cognitive problems in children.
Article in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Associations Between Teenage Motherhood, Perinatal Cortical Maturation, and Risk of Psychopathology in Children: The Mediating Role of Pregnancy Complications.Biological psychiatry global open science · 2026Article
- Associations between maternal adiposity during pregnancy and neonatal brain cortical development.NeuroImage · 2026Article
- Associations between transdiagnostic dimensions of psychopathology and brain structure and function in youth: What have we learned from the Adolescent Brain Cognitive Development (ABCD) study?Developmental cognitive neuroscience · 2026Article
- Parenting stress and young children's problematic media use: the serial mediating roles of parental phubbing and parent-child conflict.Frontiers in psychology · 2026Article
- Setting a research agenda for examining early risk for elevated cognitive disengagement syndrome symptoms using data from the ABCD cohort.European child & adolescent psychiatry · 2025Article
- Perinatal insult dimensions and developmental trajectories of psychotic-like experiences.Schizophrenia (Heidelberg, Germany) · 2025Article
- Effects of paternal age and interaction with smoking, alcohol consumption and maternal age on implantation failure in women undergoing ART.Scientific reports · 2025Article
- Setting a research agenda for examining early risk for elevated cognitive disengagement syndrome symptoms using data from the ABCD cohort.Research square · 2024Article
- Article
- Roles of the medial and lateral orbitofrontal cortex in major depression and its treatment.Molecular psychiatry · 2024Review
- Associations of parental age at pregnancy with adolescent cognitive development and emotional and behavioural problems: a birth cohort in rural Western China.BMC public health · 2024Article
- Pesticides as a risk factor for cognitive impairment: Natural substances are expected to become alternative measures to prevent and improve cognitive impairment.Frontiers in nutrition · 2023Review
- Brain functional connectivities that mediate the association between childhood traumatic events, and adult mental health and cognition.EBioMedicine · 2022Article
- Severe nausea and vomiting in pregnancy: psychiatric and cognitive problems and brain structure in children.BMC medicine · 2020Article
- The orbitofrontal cortex: reward, emotion and depression.Brain communications · 2020Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveTo investigate the relation between parental age, and behavioral, cognitive and brain differences in the children.
methodData with children aged 9-11 of 8709 mothers with parental age 15-45 years were analyzed from the Adolescent Brain Cognitive Development (ABCD) study. A general linear model was used to test the associations of the parental age with brain structure, and behavioral and cognitive problems scores.
resultsBehavioral and cognitive problems were greater in the children of the younger mothers, and were associated with lower volumes of cortical regions in the children. There was a linear correlation between the behavioral and cognitive problems scores, and the lower brain volumes (r > 0.6), which was evident when parental age was included as a stratification factor. The regions with lower volume included the anterior cingulate cortex, medial and lateral orbitofrontal cortex and amygdala, parahippocampal gyrus and hippocampus, and temporal lobe (FDR corrected p < 0.01). The lower cortical volumes and areas in the children significantly mediated the association between the parental age and the behavioral and cognitive problems in the children (all p < 10
conclusionsLower parental age is associated with behavioral problems and reduced cognitive performance in the children, and these differences are related to lower volumes and areas of some cortical regions which mediate the effects in the children. The findings are relevant to psychiatric understanding and assessment.
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