Evidence map›Paper›PMID 34650199›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2022

Phenotyping respiratory decompensation following definitive closure of the patent ductus arteriosus in preterm infants.

Craig R Wheeler, Daniel Gagner, Holly Stephens, Amelia Kraus, David Zurakowski, Kevin G Friedman, Juan C Ibla, Ryan Callahan, Diego Porras, Philip T Levy

Abstract read
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In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Changes in cardiorespiratory status after transcatheter patent ductus arteriosus closure.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Craig R WheelerDepartment of Respiratory Care, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5384-3472
Daniel GagnerDepartment of Respiratory Care, Boston Children's Hospital, Boston, MA, USA.
Holly StephensDepartment of Respiratory Care, Boston Children's Hospital, Boston, MA, USA.
Amelia KrausDepartment of Respiratory Care, Boston Children's Hospital, Boston, MA, USA.
David ZurakowskiDepartments of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3610-6942
Kevin G FriedmanDepartment of Cardiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Juan C IblaDepartments of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Ryan CallahanDepartment of Cardiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Diego PorrasDepartment of Cardiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Philip T LevyDivision of Newborn Medicine, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Harvard University, Boston, MA, USA. Philip.Levy@childrens.harvard.edu.ORCID http://orcid.org/0000-0001-5103-5834
Boston Children's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo identify risk factors associated with high-frequency ventilation (HFV) following definitive closure of the patent ductus arteriosus (PDA).

methodsWe performed a retrospective study of premature infants (<37 weeks) who were mechanically ventilated before and after surgical or transcatheter PDA closure. Primary outcome was HFV requirement within 24 h of procedure. Logistic regression was used to estimate clinical associations with post procedure HFV requirement.

resultsWe identified 110 infants who were mechanically ventilated before PDA closure, of which 48 (44%) escalated to HFV within 24 h after closure. In the multivariable model, surgical ligation (OR 21.5, 95% CI 1.6-284), elevated Respiratory Severity Score (RSS) 1 h post-procedure (OR 1.78, 95% CI 1.07-2.99) and 12 h post-procedure (OR 2.12, 95% CI 1.37-3.26) were independent predictors of HFV.

conclusionSurgical ligation and elevated RSS values over the first 12 h after PDA closure are risk factors for HFV.

Indexed as

Ductus Arteriosus, PatentHumansInfantInfant, Low Birth WeightInfant, NewbornInfant, PrematureLigationRetrospective Studies

Identifiers

PMID34650199
OpenAlexW3206317126

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.