Evidence map›Paper›PMID 34650190›Full record

ArticleScientific reports2021

Development and prospective validation of COVID-19 chest X-ray screening model for patients attending emergency departments.

Ignat Drozdov, Benjamin Szubert, Elaina Reda, Peter Makary, Daniel Forbes, Sau Lee Chang, Abinaya Ezhil, Srikanth Puttagunta, Mark Hall, Chris Carlin and 1 more

Abstract readMulticenter StudyValidation Study
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ignat DrozdovBering Limited, London, UK. idrozdov@beringresearch.com.
Benjamin SzubertBering Limited, London, UK.
Elaina RedaNHS Greater Glasgow and Clyde, Glasgow, UK.
Peter MakaryNHS Greater Glasgow and Clyde, Glasgow, UK.
Daniel ForbesNHS Greater Glasgow and Clyde, Glasgow, UK.
Sau Lee ChangNHS Greater Glasgow and Clyde, Glasgow, UK.
Abinaya EzhilNHS Greater Glasgow and Clyde, Glasgow, UK.
Srikanth PuttaguntaNHS Greater Glasgow and Clyde, Glasgow, UK.
Mark HallNHS Greater Glasgow and Clyde, Glasgow, UK.
Chris CarlinNHS Greater Glasgow and Clyde, Glasgow, UK.
David J LoweNHS Greater Glasgow and Clyde, Glasgow, UK.

Funding

Innovate UK 104690
6 · The paper itself

Abstract

Chest X-rays (CXRs) are the first-line investigation in patients presenting to emergency departments (EDs) with dyspnoea and are a valuable adjunct to clinical management of COVID-19 associated lung disease. Artificial intelligence (AI) has the potential to facilitate rapid triage of CXRs for further patient testing and/or isolation. In this work we develop an AI algorithm, CovIx, to differentiate normal, abnormal, non-COVID-19 pneumonia, and COVID-19 CXRs using a multicentre cohort of 293,143 CXRs. The algorithm is prospectively validated in 3289 CXRs acquired from patients presenting to ED with symptoms of COVID-19 across four sites in NHS Greater Glasgow and Clyde. CovIx achieves area under receiver operating characteristic curve for COVID-19 of 0.86, with sensitivity and F1-score up to 0.83 and 0.71 respectively, and performs on-par with four board-certified radiologists. AI-based algorithms can identify CXRs with COVID-19 associated pneumonia, as well as distinguish non-COVID pneumonias in symptomatic patients presenting to ED. Pre-trained models and inference scripts are freely available at https://github.com/beringresearch/bravecx-covid .

Indexed as

AlgorithmsArtificial IntelligenceCOVID-19COVID-19 TestingEmergency Service, HospitalHumansLungNeural Networks, ComputerProspective StudiesRadiography, ThoracicSARS-CoV-2Sensitivity and Specificity

Identifiers

PMID34650190
PMCPMC8516957

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.