Evidence map›Paper›PMID 34650180›Full record

ArticleScientific reports2021

Association between baseline LH/FSH and live-birth rate after fresh-embryo transfer in polycystic ovary syndrome women.

Nian-Jun Su, Cui-Yu Huang, Jie Liu, De-Ying Kang, Song-Lu Wang, Liu-Jun Liao, Jin-di Yang, Xi-Qian Zhang, Feng-Hua Liu

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  10. Dysregulated Liver Metabolism and Polycystic Ovarian Syndrome.International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nian-Jun Su *Department of Reproductive Health and Infertility, Guangdong Women and Children Hospital, 521 Xingnan Avenue, Panyu District, Guangzhou, 511442, China.
Cui-Yu Huang *Department of Reproductive Health and Infertility, Guangdong Women and Children Hospital, 521 Xingnan Avenue, Panyu District, Guangzhou, 511442, China.
Jie LiuDepartment of Vascular and Endovascular Surgery, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853, China.
De-Ying KangDepartment of Evidence Based Medicine and Clinical Epidemiology, West China Hospital, Sichuan University, 37 Guoxuexiang, Chengdu, 610041, China.
Song-Lu WangDepartment of Reproductive Health and Infertility, Guangdong Women and Children Hospital, 521 Xingnan Avenue, Panyu District, Guangzhou, 511442, China.
Liu-Jun LiaoDepartment of Reproductive Health and Infertility, Guangdong Women and Children Hospital, 521 Xingnan Avenue, Panyu District, Guangzhou, 511442, China.
Jin-di YangDepartment of Reproductive Health and Infertility, Guangdong Women and Children Hospital, 521 Xingnan Avenue, Panyu District, Guangzhou, 511442, China.
Xi-Qian ZhangDepartment of Reproductive Health and Infertility, Guangdong Women and Children Hospital, 521 Xingnan Avenue, Panyu District, Guangzhou, 511442, China.
Feng-Hua LiuDepartment of Reproductive Health and Infertility, Guangdong Women and Children Hospital, 521 Xingnan Avenue, Panyu District, Guangzhou, 511442, China. liushine2006@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to retrospectively analyse the effect of the baseline luteinising hormone/follicle-stimulating hormone ratio (bLH/FSH) on the live-birth rate per fresh-embryo transfer cycle (LBR/ET) in infertile women with polycystic ovary syndrome (PCOS) who received a fresh-embryo transfer. A total of 424 patients with PCOS who underwent the first cycle of in vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) fresh-embryo transfer at our hospital was enrolled. Univariate and multivariate logistic regression analyses, along with curve fitting and a threshold effect analysis, were performed. Baseline LH/FSH levels were a significant (P < 0.05) independent risk factor affecting live birth. In the first IVF/ICSI antagonist treatment cycles, LBR/ET after fresh-embryo transfer was relatively flat, until bLH/FSH was 1.0; thereafter, it started to decrease by 17% for every 0.1-unit bLH/FSH increase. Considering the decline in LBR/ET, it is recommended that PCOS women with bLH/FSH > 1.0 carefully consider fresh-embryo transfer during their first IVF/ICSI.

Indexed as

Birth RateAdultChinaCohort StudiesEmbryo TransferFemaleFertilization in VitroFollicle Stimulating HormoneHumansInfertility, FemaleLuteinizing HormonePolycystic Ovary SyndromePregnancyRetrospective StudiesSperm Injections, IntracytoplasmicFollicle Stimulating HormoneLuteinizing Hormone

Identifiers

PMID34650180
PMCPMC8516967

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.