ArticleNPJ microgravity2021
Opposite response of blood vessels in the retina to 6° head-down tilt and long-duration microgravity.
Article in NPJ microgravity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Spaceflight-associated neuro-ocular syndrome (SANS): expert consensus on diagnosis and management.Eye (London, England) · 2026Review
- Physical exercise protects cardiovascular fitness in long-term spaceflight: what have we learned?Science China. Life sciences · 2026Review
- A computational model for retinal haemodynamics under gravitational and postural variations.The Journal of physiology · 2026Article
- Photoacoustic microscopy for studying mechano-transduction response in resistance vessels.Photoacoustics · 2025Article
- Retinal venular vessel diameters are smaller during ten days of bed rest.Scientific reports · 2023Article
- Spaceflight associated neuro-ocular syndrome (SANS): an update on potential microgravity-based pathophysiology and mitigation development.Eye (London, England) · 2023Review
- Gravitational effects on carotid and jugular characteristics in graded head-up and head-down tilt.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Choroidal circulation disturbance is an initial factor in outer retinal degeneration in rats under simulated weightlessness.Frontiers in physiology · 2023Article
- Comparison of Retinal Imaging Techniques in Individuals with Pulmonary Artery Hypertension Using Vessel Generation Analysis.Life (Basel, Switzerland) · 2022Article
- Extrapulmonary manifestations of pulmonary arterial hypertension.Expert review of respiratory medicineReview
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 1 country.
Funding
Abstract
The Spaceflight Associated Neuro-ocular Syndrome (SANS), associated with the headward fluid shifts incurred in microgravity during long-duration missions, remains a high-priority health and performance risk for human space exploration. To help characterize the pathophysiology of SANS, NASA's VESsel GENeration Analysis (VESGEN) software was used to map and quantify vascular adaptations in the retina before and after 70 days of bed rest at 6-degree Head-Down Tilt (HDT), a well-studied microgravity analog. Results were compared to the retinal vascular response of astronauts following 6-month missions to the International Space Station (ISS). By mixed effects modeling, the trends of vascular response were opposite. Vascular density decreased significantly in the 16 retinas of eight astronauts and in contrast, increased slightly in the ten retinas of five subjects after HDT (although with limited significance). The one astronaut retina diagnosed with SANS displayed the greatest vascular loss. Results suggest that microgravity is a major variable in the retinal mediation of fluid shifts that is not reproduced in this HDT bed rest model.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.