ArticleNature communications2021
Genomic analysis finds no evidence of canonical eukaryotic DNA processing complexes in a free-living protist.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 61 citations in OpenAlex.
- Serial innovations by Asgard archaea shaped the DNA replication machinery of the early eukaryotic ancestor.Nature ecology & evolution · 2025Article
- Cell cycle regulation has shaped replication origins in budding yeast.Nature structural & molecular biology · 2025Article
- Evolutionary Insights into the Length Variation of DNA Damage Response Proteins Across Eukaryotes.Genome biology and evolution · 2025Article
- The expanded genome of Hexamita inflata, a free-living diplomonad.Scientific data · 2025Article
- Article
- A unique symbiosome in an anaerobic single-celled eukaryote.Nature communications · 2024Article
- Expanded gene and taxon sampling of diplomonads shows multiple switches to parasitic and free-living lifestyle.BMC biology · 2024Article
- Extreme mitochondrial reduction in a novel group of free-living metamonads.Nature communications · 2024Article
- Comparative genomics of Ascetosporea gives new insight into the evolutionary basis for animal parasitism in Rhizaria.BMC biology · 2024Article
- CryptoCEN: A Co-Expression Network for Cryptococcus neoformans reveals novel proteins involved in DNA damage repair.PLoS genetics · 2024Article
- Massive intein content inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Genomic survey maps differences in the molecular complement of vesicle formation machinery between Giardia intestinalis assemblages.PLoS neglected tropical diseases · 2023Article
- CryptoCEN: A Co-Expression Network forbioRxiv : the preprint server for biology · 2023Article
- Article
- Draft Genome Sequence of Aduncisulcus paluster, a Free-Living Microaerophilic Eukaryote Belonging to the Fornicata.Microbiology resource announcements · 2023Article
- Origins of DNA replication in eukaryotes.Molecular cell · 2023Review
- Combined nanometric and phylogenetic analysis of unique endocytic compartments in Giardia lamblia sheds light on the evolution of endocytosis in Metamonada.BMC biology · 2022Article
- Composition and organization of kinetochores show plasticity in apicomplexan chromosome segregation.The Journal of cell biology · 2022Article
- Variation in haplotypes in single cysts of assemblages C and D, but not of assemblage E of Giardia duodenalis.BMC microbiology · 2022Article
- Plasticity in centromere organization and kinetochore composition: Lessons from diversity.Current opinion in cell biology · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 6 institutions in 7 countries.
Funding
Abstract
Cells replicate and segregate their DNA with precision. Previous studies showed that these regulated cell-cycle processes were present in the last eukaryotic common ancestor and that their core molecular parts are conserved across eukaryotes. However, some metamonad parasites have secondarily lost components of the DNA processing and segregation apparatuses. To clarify the evolutionary history of these systems in these unusual eukaryotes, we generated a genome assembly for the free-living metamonad Carpediemonas membranifera and carried out a comparative genomics analysis. Here, we show that parasitic and free-living metamonads harbor an incomplete set of proteins for processing and segregating DNA. Unexpectedly, Carpediemonas species are further streamlined, lacking the origin recognition complex, Cdc6 and most structural kinetochore subunits. Carpediemonas species are thus the first known eukaryotes that appear to lack this suite of conserved complexes, suggesting that they likely rely on yet-to-be-discovered or alternative mechanisms to carry out these fundamental processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.