Evidence map›Paper›PMID 34649987›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Cadmium hijacks the high zinc response by binding and activating the HIZR-1 nuclear receptor.

Brian J Earley, Ciro Cubillas, Kurt Warnhoff, Raheel Ahmad, Alan Alcantar, Maximilian D Lyon, Daniel L Schneider, Kerry Kornfeld

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Chemical Genetics inACS chemical biology · 2024
    Article
  7. Toxicity Tolerance in the Carcinogenesis of Environmental Cadmium.International journal of molecular sciences · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Effects of Cadmium Exposure on Gut Villi inInternational journal of molecular sciences · 2022
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Brian J EarleyDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-6707-6785
Ciro CubillasDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110.
Kurt WarnhoffDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-9503-0557
Raheel AhmadDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-7189-2056
Alan AlcantarDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-2089-0309
Maximilian D LyonDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-2930-1726
Daniel L SchneiderDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0001-9408-8901
Kerry KornfeldDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110 kornfeld@wustl.edu.
Washington University in St. Louis · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
TRANSCRIPTIONAL REGULATION OF ZINC HOMEOSTASISR01GM068598 · NIGMS · WASHINGTON UNIVERSITY · PI KORNFELD, KERRY · 2003 to 2025
$5.3M
Zinc is a Novel Ligand of Nuclear ReceptorsF31ES030622 · NIEHS · WASHINGTON UNIVERSITY · PI EARLEY, BRIAN JAMES · 2019 to 2020
$59k
NIEHS NIH HHS F31 ES030622NIGMS NIH HHS R01 GM068598NIH HHS P40 OD010440
6 · The paper itself

Abstract

Cadmium is an environmental pollutant and significant health hazard that is similar to the physiological metal zinc. In

Indexed as

AnimalsCadmiumCaenorhabditis elegansCaenorhabditis elegans ProteinsHomeostasisLigandsMetallothioneinProtein BindingReceptors, Cytoplasmic and NuclearZincCadmiumCaenorhabditis elegans ProteinsHIZR-1 protein, C elegansLigandsMetallothioneinReceptors, Cytoplasmic and NuclearZinccadmium transcriptional responsenuclear receptorzinc homeostasiszinc sensor

Identifiers

PMID34649987
PMCPMC8594570
OpenAlexW3205420130

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.