Trial reportPediatrics2021
Constraint-Induced Movement Therapy for Cerebral Palsy: A Randomized Trial.
Trial report in Pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Modified Constraint Induced Movement Therapy on Range of Motion, Function and Disability in Children With Obstetric Brachial Plexus Injury
Efficacy of Constraint Induced Movement Therapy Delivered by Tele-Video for Children With Hemiplegic Cerebral Palsy
EFFECTS of INSTRUMENT-ASSISTED SOFT TISSUE MOBILIZATION VS. NEURODEVELOPMENTAL THERAPY on MOTOR FUNCTION in CHILDREN with GMFCS LEVEL I and II SPASTIC DIPLEGIC CEREBRAL PALSY
Implementation of Therapy Together With Early Childhood Intervention
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Neuroimaging and Neurological Outcomes in Perinatal Arterial Ischemic Stroke: A Systematic Review and Meta-Analysis.Pediatric neurology · 2024Pooled it
- Combining Multisensory Cueing and Velocity-Based Training to Enhance Shot Put Performance in an F12 Para-Athlete: A Case Report.Sports (Basel, Switzerland) · 2026Article
- Perinatal Arterial Ischemic Stroke Phase 3 Trial Protocol for Intensive Infant-Toddler Rehabilitation (I-ACQUIRE).Stroke · 2026Article
- Development of a Practical Guide for Pediatric Constraint-Induced Movement Therapy: Enhancing Understanding and Informed Decision-Making.The American journal of occupational therapy : official publication of the American Occupational Therapy Association · 2026Article
- Comparative Efficacy RCT of 3 Intensive Infant/Toddler Therapies for Unilateral Cerebral Palsy.Pediatrics open science · 2026Article
- Exploring Parent Perspectives of Feasibility After Intensive Telerehabilitation for Children with Unilateral Cerebral Palsy: A Mixed Methods Study.Journal of developmental and physical disabilities · 2026Article
- Enhancing Grip Strength and Manual Dexterity in Unilateral Cerebral Palsy: A Randomized Trial of Mirror Visual Feedback vs. Modified Constraint-Induced Movement Therapy.Brain sciences · 2025Article
- Caregiver determinants and capacity for participation in constraint-induced movement therapy.Frontiers in pediatrics · 2025Article
- Paradoxes in pediatric rehabilitation: building an interdisciplinary, total-child framework to promote effective interventions and life course well-being.Frontiers in pediatrics · 2025Article
- Project Initiate: A Clinical Feasibility Trial of Equitable Access to Early Neurodevelopmental Therapy.Journal of clinical medicine · 2024Article
- Young Children Benefit from Intensive, Group-Based Pediatric Constraint-Induced Movement Therapy.Healthcare (Basel, Switzerland) · 2024Article
- Narrative Review of the Theoretical-Methodological Foundations of the TREINI Program.Children (Basel, Switzerland) · 2024Review
- A Pilot Feasibility Study on the Use of Dual-Joystick-Operated Ride-on Toys in Upper Extremity Rehabilitation for Children with Unilateral Cerebral Palsy.Children (Basel, Switzerland) · 2024Article
- A Training Program Using Modified Joystick-Operated Ride-on Toys to Complement Conventional Upper Extremity Rehabilitation in Children with Cerebral Palsy: Results from a Pilot Study.Bioengineering (Basel, Switzerland) · 2024Article
- Pertinence of Constraint-Induced Movement Therapy in Neurological Rehabilitation: A Scoping Review.Cureus · 2023Article
- Evidence for Using ACQUIRE Therapy in the Clinical Application of Intensive Therapy: A Framework to Guide Therapeutic Interactions.Behavioral sciences (Basel, Switzerland) · 2023Article
- Outcomes Associated with a Single Joystick-Operated Ride-on-Toy Navigation Training Incorporated into a Constraint-Induced Movement Therapy Program: A Pilot Feasibility Study.Behavioral sciences (Basel, Switzerland) · 2023Article
- Hybrid Telehealth Pediatric Constraint Induced Movement Therapy Compared to In-person Intervention: A Case Series.International journal of telerehabilitation · 2023Article
- Exploring the Intensity, Frequency, and Duration of Pediatric Constraint Induced Movement Therapy Published Research: A Content Analysis.Children (Basel, Switzerland) · 2022Article
- Childhood stroke.Nature reviews. Disease primers · 2022Review
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
objectivesWith the Children with Hemiparesis Arm and Hand Movement Project (CHAMP) multisite factorial randomized controlled trial, we compared 2 doses and 2 constraint types of constraint-induced movement therapy (CIMT) to usual customary treatment (UCT).
methodsCHAMP randomly assigned 118 2- to 8-year-olds with hemiparetic cerebral palsy to one of 5 treatments with assessments at baseline, end of treatment, and 6 months posttreatment. Primary blinded outcomes were the assisting hand assessment; Peabody Motor Development Scales, Second Edition, Visual Motor Integration; and Quality of Upper Extremity Skills Test Dissociated Movement. Parents rated functioning on the Pediatric Evaluation of Disabilities Inventory-Computer Adaptive Test Daily Activities and Child Motor Activity Log How Often scale. Analyses were focused on blinded and parent-report outcomes and rank-order gains across all measures.
resultsFindings varied in statistical significance when analyzing individual blinded outcomes. parent reports, and rank-order gains. Consistently, high-dose CIMT, regardless of constraint type, produced a pattern of greatest short- and long-term gains (1.7% probability of occurring by chance alone) and significant gains on visual motor integration and dissociated movement at 6 months. O'Brien's rank-order analyses revealed high-dose CIMT produced significantly greater improvement than a moderate dose or UCT. All CIMT groups improved significantly more in parent-reported functioning, compared with that of UCT. Children with UCT also revealed objective gains (eg, 48% exceeded the smallest-detectable assisting hand assessment change, compared with 71% high-dose CIMT at the end of treatment).
conclusionsCHAMP provides novel albeit complex findings: although most individual blinded outcomes fell below statistical significance for group differences, high-dose CIMT consistently produced the largest improvements at both time points. An unexpected finding concerns shifts in UCT toward higher dosages, with improved outcomes compared with previous reports.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.