Evidence map›Paper›PMID 34649947›Full record

ArticleCancer research2021

Antisense RNAs Influence Promoter Usage of Their Counterpart Sense Genes in Cancer.

Fernando Bellido Molias, Andre Sim, Ka Wai Leong, Omer An, Yangyang Song, Vanessa Hui En Ng, Max Wei Jie Lim, Chen Ying, Jasmin Xin Jia Teo, Jonathan Göke and 1 more

Open access · greenAbstract read
In one paragraph

Article in Cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Hepatocyte Nuclear Factor 4 Alpha: A Key Regulator of Liver Disease Pathology and Haemostatic Disorders.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Antisense lncRNAFrontiers in molecular biosciences · 2023
    Article
  7. Natural antisense transcripts as drug targets.Frontiers in molecular biosciences · 2022
    Review
  8. Non-coding antisense transcripts: fine regulation of gene expression in cancer.Computational and structural biotechnology journal · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Fernando Bellido MoliasCancer Science Institute of Singapore, National University of Singapore, Singapore.
Andre SimComputational and Systems Biology, Genome Institute of Singapore, Singapore.
Ka Wai LeongCancer Science Institute of Singapore, National University of Singapore, Singapore.
Omer AnCancer Science Institute of Singapore, National University of Singapore, Singapore.ORCID 0000-0002-5762-6253
Yangyang SongCancer Science Institute of Singapore, National University of Singapore, Singapore.
Vanessa Hui En NgCancer Science Institute of Singapore, National University of Singapore, Singapore.
Max Wei Jie LimCancer Science Institute of Singapore, National University of Singapore, Singapore.
Chen YingComputational and Systems Biology, Genome Institute of Singapore, Singapore.
Jasmin Xin Jia TeoCancer Science Institute of Singapore, National University of Singapore, Singapore.
Jonathan GökeComputational and Systems Biology, Genome Institute of Singapore, Singapore. polly_chen@nus.edu.sg gokej@gis.a-star.edu.sg.
Leilei ChenCancer Science Institute of Singapore, National University of Singapore, Singapore. polly_chen@nus.edu.sg gokej@gis.a-star.edu.sg.
National University of Singapore · SGGenome Institute of Singapore · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple noncoding natural antisense transcripts (ncNAT) are known to modulate key biological events such as cell growth or differentiation. However, the actual impact of ncNATs on cancer progression remains largely unknown. In this study, we identified a complete list of differentially expressed ncNATs in hepatocellular carcinoma. Among them, a previously undescribed ncNAT

Indexed as

Promoter Regions, GeneticAnimalsBiomarkers, TumorCarcinoma, HepatocellularCholine KinaseGene Expression Regulation, NeoplasticHepatocyte Nuclear Factor 4HumansLiver NeoplasmsMaleMembrane ProteinsMiceMice, SCIDPrognosisRNA, AntisenseSphingosine N-AcyltransferaseBiomarkers, TumorCERS2 protein, humanCHKA protein, humanCholine KinaseHepatocyte Nuclear Factor 4HNF4A protein, humanMembrane ProteinsRNA, AntisenseSphingosine N-AcyltransferaseTumor Suppressor Proteins

Identifiers

PMID34649947
PMCPMC9397637
OpenAlexW3207281326

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.