Evidence map›Paper›PMID 34649930›Full record

ArticleGenome research2021

Genome-wide oscillations in G + C density and sequence conservation.

Zarmik Moqtaderi, Susan Brown, Welcome Bender

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zarmik MoqtaderiDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.ORCID 0000-0002-2785-7034
Susan BrownDepartment of Biology, Kansas State University, Manhattan, Kansas 66506, USA.
Welcome BenderDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

Funding

Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Douglas E Wright · 2012 to 2026
$63.0M
MOLECULAR MECHANISMS OF YEAST TRANSCRIPTIONAL INITIATIONR01GM030186 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI STRUHL, KEVIN · 1985 to 2018
$13.6M
MOLECULAR GENETICS OF TWO LOCIR01GM028630 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI BENDER, WELCOME · 1985 to 2017
$3.8M
NIGMS NIH HHS P20 GM103418NIGMS NIH HHS R01 GM028630NIGMS NIH HHS R01 GM030186
6 · The paper itself

Abstract

Eukaryotic genomes typically show a uniform G + C content among chromosomes, but on smaller scales, many species have a G + C density that fluctuates with a characteristic wavelength. This oscillation is evident in many insect species, with wavelengths ranging between 700 bp and 4 kb. Measures of evolutionary conservation oscillate in phase with G + C content, with conserved regions having higher G + C. Loci with large regulatory regions show more regular oscillations; coding sequences and heterochromatic regions show little or no oscillation. There is little oscillation in vertebrate genomes in regions with densely distributed mobile repetitive elements. However, species with few repeats show oscillation in both G + C density and sequence conservation. These oscillations may reflect optimal spacing of

Indexed as

GenomeRegulatory Sequences, Nucleic AcidBase SequenceBiological EvolutionConserved SequenceEvolution, MolecularRepetitive Sequences, Nucleic Acid

Identifiers

PMID34649930
PMCPMC8559709

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.