Evidence map›Paper›PMID 34649926›Full record

ArticleDiabetes2021

Novel Human Insulin Isoforms and Cα-Peptide Product in Islets of Langerhans and Choroid Plexus.

Qing-Rong Liu, Min Zhu, Pingbo Zhang, Caio H Mazucanti, Nicholas S Huang, Doyle L Lang, Qinghua Chen, Pavan Auluck, Stefano Marenco, Jennifer F O'Connell and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Diabetes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Qing-Rong LiuDiabetes Section, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD.ORCID 0000-0001-8477-6452
Min ZhuLongitudinal Study Section, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD.
Pingbo ZhangLongitudinal Study Section, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD.
Caio H MazucantiDiabetes Section, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD.
Nicholas S HuangDiabetes Section, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD.
Doyle L LangDiabetes Section, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD.
Qinghua ChenDiabetes Section, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD.
Pavan AuluckHuman Brain Collection Core, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD.
Stefano MarencoHuman Brain Collection Core, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD.
Jennifer F O'ConnellDiabetes Section, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD.
Luigi FerrucciLongitudinal Study Section, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD.
Chee W ChiaDiabetes Section, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD.
Josephine M EganDiabetes Section, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD eganj@grc.nia.nih.gov.ORCID 0000-0002-8945-0053
National Institutes of Health · US

Funding

Procurement and Characterization of Postmortem Brain TissueZICMH002903 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MARENCO, STEFANO · 2009 to 2025
$56.0M
The Human Islet Distribution Coordinating Center (UC4)UC4DK098085 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI EVANS-MOLINA, CARMELLA, NILAND, JOYCE CAROL · 2012 to 2017
$25.6M
Integrated Islet Distribution Program (U24) - 2021U24DK098085 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Carmella Evans-Molina, Joyce Carol Niland · 2021 to 2026
$17.8M
Intramural NIH HHS ZIC MH002903NIDDK NIH HHS U24 DK098085NIDDK NIH HHS UC4 DK098085
6 · The paper itself

Abstract

Human insulin (

Indexed as

AdultAmino Acid SequenceAmyloidAnimalsAutopsyChoroid PlexusC-PeptideHumansInsulinIslet Amyloid PolypeptideIslets of LangerhansMiceProinsulinProtein IsoformsAmyloidC-PeptideInsulinIslet Amyloid PolypeptideProinsulinProtein Isoforms

Identifiers

PMID34649926
PMCPMC8660980
OpenAlexW3207244959

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.