ArticleNeurology2021
Acute Ischemic Stroke Interventions in the United States and Racial, Socioeconomic, and Geographic Disparities.
Article in Neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Pooled it
- The Neutrophil to Lymphocyte Ratio in Poststroke Infection: A Systematic Review and Meta-Analysis.Disease markers · 2022Pooled it
- Disparities in Prehospital Stroke Care: Neighbourhood Socioeconomic Status and Delays in Hospital Presentation.Cerebrovascular diseases (Basel, Switzerland) · 2026Article
- Temporal Trends and Drivers of Socioeconomic Inequalities in Stroke Care, Survival, and Long-Term Outcomes.Journal of the American Heart Association · 2026Article
- Transcending Social and Cultural Barriers to Transform Global Stroke Care: An SVIN Mission Thrombectomy Initiative.Stroke (Hoboken, N.J.) · 2026Review
- Hospital Socioeconomic Status and Acute Stroke Treatment in the United States.Cerebrovascular diseases (Basel, Switzerland) · 2026Article
- Ethnic Inequalities in Return to Work Post First Stroke: Findings From a Population-Based Cohort Study in South London.Journal of the American Heart Association · 2026Article
- Race- and Ethnicity-Specific Hospital Arrival and Emergency Medicine Service Activation Times by US State for Ischemic Stroke.Journal of the American Heart Association · 2026Article
- US Burden of Disorders Affecting the Nervous System: From the Global Burden of Disease 2021 Study.JAMA neurology · 2026Article
- Health disparities in neurology.Nature reviews. Neurology · 2025Review
- Hospital Implementation of Endovascular Thrombectomy and Health Equity in Acute Stroke Outcomes.Stroke · 2025Observational
- Disparities in Community-Based Rehabilitation Following Stroke: Findings From the COMPASS Trial.Journal of the American Heart Association · 2025Observational
- Individual and County-Level Social Determinants of Health and Acute Reperfusion Therapies: Get With The Guidelines-Stroke Registry Results.Journal of the American Heart Association · 2025Article
- Article
- Variations in Methodological Approaches to Measuring Health Inequalities and Inequities: A Scoping Review of Acute Stroke Pathways.Healthcare (Basel, Switzerland) · 2025Review
- Financial Concerns Are Common Among Family Surrogate Decision-Makers of Patients With Stroke: A Mixed Methods Study.Neurology. Clinical practice · 2025Article
- Socioeconomic Status and Stroke: A Review of the Latest Evidence on Inequalities and Their Drivers.Stroke · 2025Review
- Racial disparities in access to, and outcomes of, acute ischaemic stroke treatments in the USA.Stroke and vascular neurology · 2025Article
- No disadvantages for women in acute stroke care in Germany: an analysis of access to stroke treatment services in Germany from 2017 to 2022.Neurological research and practice · 2025Article
- Trends in Ethnic Disparities in Stroke Care and Long-Term Outcomes.JAMA network open · 2025Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
objectivesIn patients with ischemic stroke (IS), IV alteplase (tissue plasminogen activator [tPA]) and endovascular thrombectomy (EVT) reduce long-term disability, but their utilization has not been fully optimized. Prior research has also demonstrated disparities in the use of tPA and EVT specific to sex, race/ethnicity, socioeconomic status, and geographic location. We sought to determine the utilization of tPA and EVT in the United States from 2016-2018 and if disparities in utilization persist.
methodsThis is a retrospective, longitudinal analysis of the 2016-2018 National Inpatient Sample. We included adult patients who had a primary discharge diagnosis of IS. The primary study outcomes were the proportions who received tPA or EVT. We fit a multivariate logistic regression model to our outcomes in the full cohort and also in the subset of patients who had an available baseline National Institutes of Health Stroke Scale (NIHSS) score.
resultsThe full cohort after weighting included 1,439,295 patients with IS. The proportion who received tPA increased from 8.8% in 2016 to 10.2% in 2018 ( DISCUSSION: Utilization of tPA and EVT for IS in the United States increased from 2016 to 2018. There are racial, socioeconomic, and geographic disparities in the accessibility of tPA and EVT for patients with IS, with important public health implications that require further study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.