Evidence map›Paper›PMID 34649703›Full record

ReviewJournal of the American College of Cardiology2021

Stress Cardiac Magnetic Resonance Myocardial Perfusion Imaging: JACC Review Topic of the Week.

Amit R Patel, Michael Salerno, Raymond Y Kwong, Amita Singh, Bobak Heydari, Christopher M Kramer

2 registry-linked trialsAbstract readReview
In one paragraph

Review in Journal of the American College of Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 72 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06641843 enrolling by invitationnot on this mapstarted 2024, after this paper: background citation

Magnetic Resonance Myocardial Stress Perfusion: to Improve the Myocardial Evaluation in Pediatric Patients with Cardiovascular Disease

TypeobservationalSponsorWest China Second University HospitalRan2024 to 2034Enrolled240ConditionsKawasaki Disease, Cardiovascular Disease, Anomalous Origin of Coronary Artery
NCT06964672 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Advanced Imaging With Photon Counting Computed Tomography in Heart Failure Patients: a Prospective Study

TypeobservationalSponsorUniversità Vita-Salute San RaffaeleRan2025 to 2030Enrolled150ConditionsHeart Failure
3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  12. Observational
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  14. Myocardial perfusion imaging in advanced coronary artery disease.European journal of clinical investigation · 2025
    Review
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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Amit R PatelDepartment of Medicine University of Chicago, Chicago, Illinois, USA; Department of Radiology, University of Chicago, Chicago, Illinois, USA. Electronic address: amitpatel@uchicago.edu.
Michael SalernoCardiovascular Division, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA; Department of Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, Virginia, USA; Department of Biomedical Engineering, University of Virginia Health System, Charlottesville, Virginia, USA.
Raymond Y KwongCardiovascular Division, Department of Medicine, Brigham and Woman's Hospital, Boston, Massachusetts, USA.
Amita SinghDepartment of Medicine University of Chicago, Chicago, Illinois, USA.
Bobak HeydariCardiovascular Division, Department of Medicine, University of Calgary, Calgary, Alberta, Canada.
Christopher M KramerCardiovascular Division, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA; Department of Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, Virginia, USA.

Funding

HCMR Novel Markers of Prognosis in Hypertrophic CardiomyopathyU01HL117006 · NHLBI · UNIVERSITY OF VIRGINIA · PI KRAMER, CHRISTOPHER M., NEUBAUER, STEFAN · 2013 to 2017
$14.5M
Comprehensive Magnetic Resonance in PADR01HL075792 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI KRAMER, CHRISTOPHER M. · 2003 to 2021
$10.5M
High-Resolution Whole Heart Quantitative CMR Perfusion Imaging in Ischemic Heart DiseaseR01HL131919 · NHLBI · UNIVERSITY OF VIRGINIA · PI ENNIS, DANIEL B · 2017 to 2021
$3.5M
Rapid Free-Breathing Self-Gated Spiral Pulse Sequences for Simultaneous Cine and T1 mappingR01HL155962 · NHLBI · UNIVERSITY OF VIRGINIA · PI SALERNO, MICHAEL · 2021 to 2024
$2.1M
NHLBI NIH HHS R01 HL075792NHLBI NIH HHS R01 HL131919NHLBI NIH HHS R01 HL155962NHLBI NIH HHS U01 HL117006
6 · The paper itself

Abstract

Stress cardiovascular magnetic resonance imaging (CMR) is a cost-effective, noninvasive test that accurately assesses myocardial ischemia, myocardial viability, and cardiac function without the need for ionizing radiation. There is a large body of literature, including randomized controlled trials, validating its diagnostic performance, risk stratification capabilities, and ability to guide appropriate use of coronary intervention. Specifically, stress CMR has shown higher diagnostic sensitivity than single-photon emission computed tomography imaging in detecting angiographically significant coronary artery disease. Stress CMR is particularly valuable for the evaluation of patients with moderate to high pretest probability of having stable ischemic heart disease and for patients known to have challenging imaging characteristics, including women, individuals with prior revascularization, and those with left ventricular dysfunction. This paper reviews the basics principles of stress CMR, the data supporting its clinical use, the added-value of myocardial blood flow quantification, and the assessment of myocardial function and viability routinely obtained during a stress CMR study.

Indexed as

Magnetic Resonance Imaging, CineMyocardial Perfusion ImagingCoronary Artery DiseaseHumansMyocardial IschemiaPrognosisRisk Assessmentcoronary artery diseasemagnetic resonance imagingmyocardial perfusionstable ischemic heart disease

Identifiers

PMID34649703
PMCPMC8530410

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.