Evidence map›Paper›PMID 34649580›Full record

ArticleParticle and fibre toxicology2021

The mechanism of cell death induced by silver nanoparticles is distinct from silver cations.

Monica M Rohde, Christina M Snyder, John Sloop, Shane R Solst, George L Donati, Douglas R Spitz, Cristina M Furdui, Ravi Singh

Open access · goldAbstract read
In one paragraph

Article in Particle and fibre toxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 1 synthesis or guideline pooled it, 142 citations in OpenAlex.

  1. Pooled it
  2. Silver Nanoparticles fromACS omega · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Green Synthesis of Silver Nanoparticles UsingMolecules (Basel, Switzerland) · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Monica M RohdeDepartment of Cancer Biology, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, NC, 27157, USA.
Christina M SnyderDepartment of Cancer Biology, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, NC, 27157, USA.
John SloopDepartment of Chemistry, Wake Forest University, Winston-Salem, NC, 27109, USA.
Shane R SolstFree Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.
George L DonatiDepartment of Chemistry, Wake Forest University, Winston-Salem, NC, 27109, USA.
Douglas R SpitzFree Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.
Cristina M FurduiDepartment of Internal Medicine, Section of Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.
Ravi SinghDepartment of Cancer Biology, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, NC, 27157, USA. rasingh@wakehealth.edu.ORCID 0000-0003-0750-1804
Wake Forest University · USAtrium Health Wake Forest Baptist · USUniversity of Iowa · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0M
Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Project 3: MRI Imaging of Redox Active Fe Predicts GBM Responses to Pharmacological AscorbateP01CA217797 · NCI · UNIVERSITY OF IOWA · PI BUETTNER, GARRY R · 2018 to 2022
$9.6M
Development of a novel therapeutic agent that exploits specific vulnerabilities in claudin low breast cancerR01CA207222 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SINGH, RAVI N · 2017 to 2021
$1.7M
New Oxidation-Sensing Probes to Evaluate Mitochondrial Dysfunction in Lung InjuryR33ES025645 · NIEHS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI FURDUI, CRISTINA MARIA, KING, S BRUCE · 2017 to 2019
$1.5M
New Reagents for Tracking Protein Oxidation in Cells by MS and Imaging MethodsR33CA177461 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI FURDUI, CRISTINA MARIA, POOLE, LESLIE B · 2013 to 2015
$1.0M
Redox Biology and Medicine Training ProgramT32GM127261 · NIGMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI FURDUI, CRISTINA MARIA, POOLE, LESLIE B · 2018 to 2022
$975k
NCATS NIH HHS UL1 TR001420NCI NIH HHS P01 CA217797NCI NIH HHS P30 CA012197NCI NIH HHS P30 CA086862NCI NIH HHS R01 CA207222NCI NIH HHS R33 CA177461NIEHS NIH HHS P30 ES005605NIEHS NIH HHS R33 ES025645NIGMS NIH HHS T32 GM127261
6 · The paper itself

Abstract

backgroundPrecisely how silver nanoparticles (AgNPs) kill mammalian cells still is not fully understood. It is not clear if AgNP-induced damage differs from silver cation (Ag

methodsCells were exposed to intact AgNPs, Ag

resultsWe identified AgNPs with negligible Ag

conclusionsThere are distinct differences in the responses of cells to AgNPs and Ag

Indexed as

Metal NanoparticlesSilverAnimalsCationsCell DeathHydrogen PeroxideCationsHydrogen PeroxideSilverBiosafetyBreast cancerLipid peroxidationNanotoxicologyOxidative stress

Identifiers

PMID34649580
PMCPMC8515661
OpenAlexW3207626062

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.