ArticleBMC musculoskeletal disorders2021
Histological and molecular features of the subacromial bursa of rotator cuff tears compared to non-tendon defects: a pilot study.
Article in BMC musculoskeletal disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Association of Subacromial Bursa Characteristics With Preoperative Nocturnal Pain and the Efficacy of Surgical Treatment for Pain Relief: A Prospective Cohort Study.Orthopaedic journal of sports medicine · 2026Article
- Effects of Overload on Imiquimod-Induced Psoriasis Model Mice: A Basic Experimental Study.Health science reports · 2026Article
- The subacromial bursa in rotator cuff injury: from pathological contributor to regenerative resource?Frontiers in bioengineering and biotechnology · 2026Review
- Removal or retention: evolving views on possible roles of the subacromial bursa in rotator cuff disease.EFORT open reviews · 2025Review
- Article
- Risk factors for rotator cuff tear in Syrian adults: a cross-sectional study.Scientific reports · 2025Article
- Biologic augmentation of rotator cuff repair with microfragmented autologous subacromial bursal tissue enveloped in a patch of compressed autologous long head of biceps tendon tissue: theJSES international · 2024Article
- The subacromial bursa modulates tendon healing after rotator cuff injury in rats.Science translational medicine · 2024Article
- Rotator cuff tears.Nature reviews. Disease primers · 2024Review
- Article
- Article
- Comparison of single platelet-rich plasma injection with hyaluronic acid injection for partial-thickness rotator cuff tears.Journal of the Chinese Medical Association : JCMA · 2022Article
- Review
- Contribution of pathogenic T helper 1 and 17 cells to bursitis and tenosynovitis in polymyalgia rheumatica.Frontiers in immunology · 2022Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of the subacromial bursa in the development or healing of shoulder pathologies is unclear. Due to this limited knowledge, we aimed to understand specific reactions of the subacromial bursa according to rotator cuff (RC) pathologies compared to non-tendon defects of the shoulder. We hypothesized that the tissue composition and inflammatory status of the bursa are likely to vary between shoulder pathologies depending on the presence and the extent of RC lesion.
methodBursa samples from patients with either 1) shoulder instability with intact RC (healthy bursa, control), 2) osteochondral pathology with intact RC, 3) partial supraspinatus (SSP) tendon tear, or 4) full-thickness SSP tear were investigated histologically and on gene expression level.
resultBursae from SSP tears differed from non-tendon pathologies by exhibiting increased chondral metaplasia and TGFβ1 expression. MMP1 was not expressed in healthy bursa controls, but strongly increased with full-thickness SSP tears. Additionally, the expression of the inflammatory mediators IL1β, IL6, and COX2 increased with the extent of SSP tear as shown by correlation analysis. In contrast, increased angiogenesis and nerve fibers as well as significantly upregulated IL6 and COX2 expression were features of bursae from patients with osteochondral pathology. Using immunohistochemistry, CD45+ leukocytes were observed in all examined groups, which were identified in particular as CD68+ monocytes/macrophages.
conclusionIn summary, besides the strong increase in MMP1 expression with SSP tear, molecular changes were minor between the investigated groups. However, expression of pro-inflammatory cytokines correlated with the severity of the SSP tear. Most pronounced tissue alterations occurred for the osteochondral pathology and full-thickness SSP tear group, which demonstrates that the bursal reaction is not exclusively dependent on the occurrence of an SSP tear rather than longstanding degenerative changes. The present bursa characterization contributes to the understanding of specific tissue alterations related to RC tears or non-tendon shoulder pathologies. This pilot study provides the basis for future studies elucidating the role of the subacromial bursa in the development or healing of shoulder pathologies.
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