Evidence map›Paper›PMID 34649512›Full record

ArticleBMC geriatrics2021

Persistent eosinopenia is associated with in-hospital mortality among older patients: unexpected prognostic value of a revisited biomarker.

Bethsabee Partouche, Marion Pepin, Pauline Mary de Farcy, Jean-Emmanuel Kahn, Bruno Sawczynski, Laurent Lechowski, Laurent Teillet, Frederic Barbot, Marie Herr, Benjamin Davido

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In one paragraph

Article in BMC geriatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Article
  8. Evaluation of Eosinopenia as a SIRS Biomarker in Critically Ill Horses.Animals : an open access journal from MDPI · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bethsabee PartoucheGeriatrics Department, Paris-Saclay University, Versailles Saint Quentin en Yvelines University (UVSQ), AP-HP Ambroise Paré Hospital, 92100, Boulogne-Billancourt, France.
Marion PepinGeriatrics Department, Paris-Saclay University, Versailles Saint Quentin en Yvelines University (UVSQ), AP-HP Ambroise Paré Hospital, 92100, Boulogne-Billancourt, France.
Pauline Mary de FarcyGeriatrics Department, Paris-Saclay University, UVSQ, AP-HP, Ste Périne Hospital, 75016, Paris, France.
Jean-Emmanuel KahnInternal Medicine Department, Paris-Saclay University, UVSQ, AP-HP, Ambroise Paré Hospital, 92100, Boulogne-Billancourt, France.
Bruno SawczynskiMedical Information Department (DIM), Paris-Saclay University, AP-HP, Ambroise Paré Hospital, 92100, Boulogne-Billancourt, France.
Laurent LechowskiGeriatrics Department, Paris-Saclay University, UVSQ, AP-HP, Ste Périne Hospital, 75016, Paris, France.
Laurent TeilletGeriatrics Department, Paris-Saclay University, Versailles Saint Quentin en Yvelines University (UVSQ), AP-HP Ambroise Paré Hospital, 92100, Boulogne-Billancourt, France.
Frederic BarbotParis-Saclay University, AP-HP, Raymond Poincaré Hospital, Clinical Investigation Center, Inserm (CIC 1429), 92380, Garches, France.
Marie HerrEpidemiology and Public Health Department, Paris-Saclay University, UVSQ, Inserm, CESP, Anti-infective evasion and pharmacoepidemiology; AP-HP, Raymond-Poincaré Hospital, 92380, Garches, France.
Benjamin DavidoInfectious and Tropical Disease Department, Paris-Saclay University, UVSQ, AP-HP, Raymond Poincaré Hospital, 92380, Garches, France. benjamin.davido@aphp.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInfection is one of the major causes of mortality and morbidity in older adults. Available biomarkers are not associated with prognosis in older patients. This study aimed to analyze the value of eosinopenia (eosinophil count< 100/mm

methodsA retrospective study was performed from 1 January to 31 December 2018 among patients in a geriatrics ward suffering from a bacterial infection treated with antibiotics. Biomarker data including the eosinophil count, neutrophil count and C-reactive protein (CRP) were collected within 4 days after patient diagnosis. Persistent eosinopenia was defined as a consistent eosinophil count< 100/mm

resultsOur study included 197 patients with a mean age of 90 ± 6 years. A total of 36 patients (18%) died during their stay in hospital. The patients who died were more likely to have persistent eosinopenia in comparison to survivors (78% versus 34%, p < 0.001). In the multivariate analysis, persistent eosinopenia was associated with in-hospital mortality with an adjusted HR of 8.90 (95%CI 3.46-22.9). The AUC for eosinophil count, CRP and neutrophil count between Day 2 and Day 4 were 0.7650, 0.7130, and 0.698, respectively.

conclusionPersistent eosinopenia within 4 days of diagnosis of bacterial infection appeared to be a predictor of in-hospital mortality in older patients.

Indexed as

EosinophilsAgedAged, 80 and overBiomarkersHospital MortalityHumansPrognosisRetrospective StudiesROC CurveBiomarkersBacterial infectionEosinopeniaGeriatricsMortalityOutcome

Identifiers

PMID34649512
PMCPMC8516088

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.