Evidence map›Paper›PMID 34649504›Full record

Observational studyBMC cardiovascular disorders2021

Complement component 7 is associated with total- and cardiac death in chest-pain patients with suspected acute coronary syndrome.

Reidun Aarsetøy, Thor Ueland, Pål Aukrust, Annika E Michelsen, Ricardo Leon de la Fuente, Heidi Grundt, Harry Staines, Ottar Nygaard, Dennis W T Nilsen

2 registry-linked trialsOpen access · goldAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC cardiovascular disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00521976 completednot on this map

An Investigation of Activated Factor XII (Fxlla) as a Prognostic Marker.

TypeobservationalSponsorHelse Stavanger HFRan2002 to 2005Enrolled871ConditionsChest Pain, Coronary Artery Disease, Unstable Angina Pectoris, Myocardial Infarction
NCT01377402 completednot on this map

ARgentinean Risk Assessment Registry in Acute Coronary Syndrome; the ARRA-RACS Study.

TypeobservationalSponsorHelse Stavanger HFRan2005 to 2010Enrolled982ConditionsChest Pain, Coronary Artery Disease, Unstable Angina Pectoris, Myocardial Infarction
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Reidun AarsetøyDepartment of Clinical Science, University of Bergen, Bergen, Norway. Reidun.Aarsetoy@uib.no.
Thor UelandRikshospitalet, Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.
Pål AukrustRikshospitalet, Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.
Annika E MichelsenRikshospitalet, Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.
Ricardo Leon de la FuenteCentro Cardiovascular Salta, Salta, Argentina.
Heidi GrundtDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Harry StainesSigma Statistical Services, Balmullo, UK.
Ottar NygaardDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Dennis W T NilsenDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Oslo University Hospital · NOUniversity of Bergen · NOHaukeland University Hospital · NORoyal Statistical Society · GBStavanger University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundComplement activation has been associated with atherosclerosis, atherosclerotic plaque destabilization and increased risk of cardiovascular events. Complement component 7 (CC7) binds to the C5bC6 complex which is part of the terminal complement complex (TCC/C5b-9). High-sensitivity C-reactive protein (hsCRP) is a sensitive marker of systemic inflammation and may reflect the increased inflammatory state associated with cardiovascular disease.

aimTo evaluate the associations between CC7 and total- and cardiac mortality in patients hospitalized with chest-pain of suspected coronary origin, and whether combining CC7 with hsCRP adds prognostic information.

methodsBaseline levels of CC7 were related to 60-months survival in a prospective, observational study of 982 patients hospitalized with a suspected acute coronary syndrome (ACS) at 9 hospitals in Salta, Argentina. A cox regression model, adjusting for conventional cardiovascular risk factors, was fitted with all-cause mortality, cardiac death and sudden cardiac death (SCD) as the dependent variables. A similar Norwegian population of 871 patients was applied to test the reproducibility of results in relation to total death.

resultsAt follow-up, 173 patients (17.7%) in the Argentinean cohort had died, of these 92 (9.4%) were classified as cardiac death and 59 (6.0%) as SCD. In the Norwegian population, a total of 254 patients (30%) died. In multivariable analysis, CC7 was significantly associated with 60-months all-cause mortality [hazard ratio (HR) 1.26 (95% confidence interval (CI), 1.07-1.47) and cardiac death [HR 1.28 (95% CI 1.02-1.60)], but not with SCD. CC7 was only weakly correlated with hsCRP (r = 0.10, p = 0.002), and there was no statistically significant interaction between the two biomarkers in relation to outcome. The significant association of CC7 with total death was reproduced in the Norwegian population.

conclusionsCC7 was significantly associated with all-cause mortality and cardiac death at 60-months follow-up in chest-pain patients with suspected ACS. CLINICAL

trial registrationClinicalTrials.gov Identifier: NCT01377402, NCT00521976.

Indexed as

Acute Coronary SyndromeAgedAged, 80 and overAngina PectorisArgentinaBiomarkersCause of DeathComplement C7C-Reactive ProteinFemaleHospitalizationHumansInflammation MediatorsMaleMiddle AgedNorwayBiomarkersComplement C7C-Reactive ProteinInflammation MediatorsAcute coronary syndromeAll-cause mortalityCardiac deathComplement component 7High-sensitivity C-reactive proteinPrognostic biomarkers

Identifiers

PMID34649504
PMCPMC8515738
OpenAlexW3206441979

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.