ArticleProceedings of the National Academy of Sciences of the United States of America1986
Human liver apolipoprotein B-100 cDNA: complete nucleic acid and derived amino acid sequence.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 181 citations in OpenAlex.
- Identification of Receptor Ligands in Apo B100 Reveals Potential Functional Domains.The protein journal · 2018Article
- Conformation and stability properties of B17: II. Analytical investigations using differential scanning calorimetry.European biophysics journal : EBJ · 2013Article
- Low-density lipoprotein modified by myeloperoxidase in inflammatory pathways and clinical studies.Mediators of inflammation · 2013Review
- Fatty acid and very low density lipoprotein metabolism in obese African American and Caucasian women with type 2 diabetes.Journal of lipid research · 2012Article
- Conformation and stability properties of B17: I. Analytical investigations using circular dichroism.European biophysics journal : EBJ · 2012Article
- Negatively cooperative binding of high-density lipoprotein to the HDL receptor SR-BI.Biochemistry · 2011Article
- Increased whole-body adiposity without a concomitant increase in liver fat is not associated with augmented metabolic dysfunction.Obesity (Silver Spring, Md.) · 2010Article
- Nucleic acid-binding properties of low-density lipoproteins: LDL as a natural gene vector.Journal of protein chemistry · 1999Article
- Use of cyclodextrin to deliver lipids and to modulate apolipoprotein B-100 production in HepG2 cells.Lipids · 1997Article
- Increased catabolic rate of low density lipoproteins in humans with cholesteryl ester transfer protein deficiency.The Journal of clinical investigation · 1995Article
- Tandem mass spectrometric characterization of a specific cysteic acid residue in oxidized human apoprotein B-100.Journal of the American Society for Mass Spectrometry · 1995Article
- Murine mammary-derived cells secrete the N-terminal 41% of human apolipoprotein B on high density lipoprotein-sized lipoproteins containing a triacylglycerol-rich core.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Accumulation of "small dense" low density lipoproteins (LDL) in a homozygous patients with familial defective apolipoprotein B-100 results from heterogenous interaction of LDL subfractions with the LDL receptor.The Journal of clinical investigation · 1993Article
- Heterogeneity of molecular weight and apolipoproteins in low density lipoproteins of healthy human males.Lipids · 1992Article
- Expression, secretion, and lipid-binding characterization of the N-terminal 17% of apolipoprotein B.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Detection by denaturing gradient gel electrophoresis of a new polymorphism in the apolipoprotein B gene.Human genetics · 1990Article
- Uptake of lactosylated low-density lipoprotein by galactose-specific receptors in rat liver.The Biochemical journal · 1990Article
- Possible role of the Golgi apparatus in the assembly of very low density lipoprotein.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- Familial hypobetalipoproteinemia caused by a mutation in the apolipoprotein B gene that results in a truncated species of apolipoprotein B (B-31). A unique mutation that helps to define the portion of the apolipoprotein B molecule required for the formation of buoyant, triglyceride-rich lipoproteins.The Journal of clinical investigation · 1990Article
- Focal accumulation of an apolipoprotein B-based synthetic oligopeptide in the healing rabbit arterial wall.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human apolipoprotein B-100 (apoB-100), the ligand on low density lipoproteins that interacts with the low density lipoprotein receptor and initiates receptor-mediated endocytosis and low density lipoprotein catabolism, has been cloned, and the complete nucleic acid and derived amino acid sequences have been determined. ApoB-100 cDNAs were isolated from normal human liver cDNA libraries utilizing immunoscreening as well as filter hybridization with radiolabeled apoB-100 oligodeoxynucleotides. The apoB-100 mRNA is 14.1 kilobases long encoding a mature apoB-100 protein of 4536 amino acids with a calculated amino acid molecular weight of 512,723. ApoB-100 contains 20 potential glycosylation sites, and 12 of a total of 25 cysteine residues are located in the amino-terminal region of the apolipoprotein providing a potential globular structure of the amino terminus of the protein. ApoB-100 contains relatively few regions of amphipathic helices, but compared to other human apolipoproteins it is enriched in beta-structure. The delineation of the entire human apoB-100 sequence will now permit a detailed analysis of the conformation of the protein, the low density lipoprotein receptor binding domain(s), and the structural relationship between apoB-100 and apoB-48 and will provide the basis for the study of genetic defects in apoB-100 in patients with dyslipoproteinemias.
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