ArticlePhotodiagnosis and photodynamic therapy2021
Retinal microvascular and perfusional disruption in paediatric COVID-19: A case-control optical coherence tomography angiography study.
Article in Photodiagnosis and photodynamic therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Effect of COVID-19 on Retinal and Choroidal Microvasculature in the Pediatric Population: A Literature Review.Medicina (Kaunas, Lithuania) · 2026Review
- COVID-19's effects on microvascular structure in a healthy retina: an OCTA study.International journal of ophthalmology · 2025Article
- The optical coherence tomography angiography study on paediatric COVID-19 cases.Photodiagnosis and photodynamic therapy · 2022Article
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Abstract
purposeTo investigate the short-term effect of coronavirus 2019 (COVID-19) on the retinal capillary network and choroid in children. MATERIALS AND
methodsThis prospective, cross-sectional, case-control study included 19 recovered COVID-19 pediatric patients and 20 healthy children. Macular thickness, choroidal thickness, vessel density (VD), perfusion density (PD), and foveal avascular zone (FAZ) values were obtained. Central vessel and perfusion densities were measured at the central 6-mm area, and the values were compared among three subgroups according to location.
resultsThe mean ages of patients and controls were 12. 42 ± 3.3 years and 13.35 ± 1.2 years, respectively. Significant differences were observed between the two groups in terms of inner, outer, and full VD, as well as inner and full PD. No significant differences in center VD and PD were observed between groups. Although it was not evident in analysis of choroidal values, inflammatory sites were thickened. FAZ area significantly differed between groups (p < 0.05).
conclusionsRetinal microvascularity was impaired in the acute phase of disease in recovered COVID-19 patients aged 10-15 years. However, the microvascularity impairment was subclinical. The choroid was thickened because of inflammation during the acute phase of disease. pediatric COVID-19 patients should undergo follow up via optical coherence tomography angiography to detect subclinical and asymptomatic retinal changes. Long-term follow-up studies are needed to validate these findings.
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