Evidence map›Paper›PMID 34648736›Full record

ArticleCell host & microbe2021

Goodbye PAM: Phage λ's Red recombination system cripples PAMs and helps dodge CRISPR attacks.

Khang Ho, Rasika M Harshey

Abstract readComment
In one paragraph

Article in Cell host & microbe, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Khang HoDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Rasika M HarsheyDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA. Electronic address: rasika@austin.utexas.edu.

Funding

Virus-host interactions and microbial ecologyR35GM118085 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI HARSHEY, RASIKA M · 2016 to 2025
$5.6M
Accelerated evolution of antibiotic resistance in a bacterial swarmR21AI158295 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI HARSHEY, RASIKA M · 2021 to 2022
$436k
NIAID NIH HHS R21 AI158295NIGMS NIH HHS R35 GM118085
6 · The paper itself

Abstract

Ever wondered how the phage λ Red recombination system resembles the Red Queen? Hossain et al. (2021) provide an answer in this issue of Cell Host & Microbe. They show that Red debilitates PAM sequences by mutagenic repair of CRISPR-targeted DNA breaks in infecting λ, thus shaping the phage-CRISPR arms race.

Indexed as

Bacteriophage lambdaClustered Regularly Interspaced Short Palindromic RepeatsRecombination, Genetic

Identifiers

PMID34648736
PMCPMC9990376

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.