Evidence map›Paper›PMID 34648729›Full record

ArticleAmerican journal of respiratory cell and molecular biology2022

Inhibition of ABCC1 Decreases cAMP Egress and Promotes Human Airway Smooth Muscle Cell Relaxation.

Gaoyuan Cao, Hong Lam, Joseph A Jude, Nikhil Karmacharya, Mengyuan Kan, William Jester, Cynthia Koziol-White, Blanca E Himes, Geoffrey L Chupp, Steven S An and 1 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Mechanistic basis for the antifibrotic actions of cAMP-based therapies.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  5. Article
  6. Review
  7. Serum cAMP levels are increased in patients with asthma.The Journal of clinical investigation · 2025
    Article
  8. Bronchomotor tone imbalance evokes airway hyperresponsiveness.Expert review of respiratory medicine · 2024
    Review
  9. Article
  10. Article
  11. Opening up to cAMP Transport Mechanisms in Airway Smooth Muscle.American journal of respiratory cell and molecular biology · 2022
    Article
  12. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Gaoyuan CaoRutgers Institute for Translational Medicine and Science, and.
Hong LamRutgers Institute for Translational Medicine and Science, and.
Joseph A JudeRutgers Institute for Translational Medicine and Science, and.
Nikhil KarmacharyaRutgers Institute for Translational Medicine and Science, and.
Mengyuan KanDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; and.
William JesterRutgers Institute for Translational Medicine and Science, and.
Cynthia Koziol-WhiteRutgers Institute for Translational Medicine and Science, and.
Blanca E HimesDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; and.
Geoffrey L ChuppDivision of Pulmonary, Critical Care and Sleep Medicine, School of Medicine, Yale University, New Haven, Connecticut.
Steven S AnRutgers Institute for Translational Medicine and Science, and.ORCID 0000-0003-4723-1888
Reynold A PanettieriRutgers Institute for Translational Medicine and Science, and.ORCID 0000-0003-0834-4636
Rutgers, The State University of New Jersey · USUniversity of Pennsylvania · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI PANOS G. GEORGOPOULOS · 1988 to 2026
$47.4M
Project 4 - OGR1- and TSPO- dependent mechanisms mediated by benzodiazepines affecting ASM contractionP01HL114471 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI LIGGETT, STEPHEN B · 2013 to 2023
$23.9M
Mechanisms of Rhinovirus-induced airway hyperresponsiveness: an airway smooth muscle perspectiveR56HL142890 · NHLBI · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · PI KOZIOL-WHITE, CYNTHIA · 2020 to 2020
$404k
NCATS NIH HHS UL1 TR001863New Jersey Alliance for Clinical and Translational Science-National Center for Advancing Translational Sciences UL1TR0030117NHLBI NIH HHS P01 HL114471NHLBI NIH HHS R56 HL142890NHLBI NIH HHS R56HL155937NIEHS NIH HHS P30 ES005022
6 · The paper itself

Abstract

In most living cells, the second-messenger roles for adenosine 3',5'-cyclic monophosphate (cAMP) are short-lived, confined to the intracellular space, and tightly controlled by the binary switch-like actions of Gα

Indexed as

Adrenergic beta-2 Receptor AgonistsAsthmaATP-Binding Cassette, Sub-Family C ProteinsChromograninsCyclic AMPGTP-Binding Protein alpha Subunits, GsHumansLungMuscle RelaxationMyocytes, Smooth MuscleRNA, Small InterferingAdrenergic beta-2 Receptor AgonistsATP-Binding Cassette, Sub-Family C ProteinsChromograninsCyclic AMPGNAS protein, humanGTP-Binding Protein alpha Subunits, Gsmultidrug resistance-associated protein 1RNA, Small Interferingairway smooth muscleasthmacAMPmultidrug resistance–associated proteinsβ2-adrenoceptor

Identifiers

PMID34648729
PMCPMC8803359
OpenAlexW3205676144

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.