Evidence map›Paper›PMID 34648622›Full record

ArticleInteractive cardiovascular and thoracic surgery2022

Circulating soluble receptor of advanced glycation end product is associated with bicuspid aortic aneurysm progression via NF-κB pathway.

Hao Jia, Le Kang, Shuyang Lu, Zhenhang Chen, Jinqiang Shen, Ben Huang, Yunzeng Zou, Yongxin Sun

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Interactive cardiovascular and thoracic surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Exploring the Anti-Inflammatory Effects ofPharmaceuticals (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hao JiaDepartment of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Le KangDepartment of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Shuyang LuDepartment of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Zhenhang ChenDepartment of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Jinqiang ShenDepartment of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Ben HuangDepartment of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Yunzeng ZouCentral Laboratory of Cardiovascular Institute, Zhongshan Hospital, Fudan University, Shanghai, China.
Yongxin SunDepartment of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.ORCID 0000-0001-9743-5622
Sun Yat-sen University · CNFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPatients with bicuspid aortic valve (BAV) have a high risk of aortic dilation and adverse vascular events. Previous studies had reported soluble receptor for advanced glycation end products (sRAGE) to compete with receptor of advanced glycation end products (RAGE) for ligand binding and inhibit the activation of nuclear-factor kappa-B (NF-κB) pathway and matrix metalloproteinases (MMP) transcription. Thus, sRAGE serum levels may contribute to the clinical diagnosis and monitoring of ascending aorta aneurysm in patients with BAV.

methodsTo eliminate the confounding factors, 44 patients with BAV were divided into 3 subgroups according to the diameter of ascending aorta, and 20 patients with tricuspid aortic valve and normal-sized ascending aorta were selected as a control group. Protein levels and gene transcription of several variates were evaluated in the tissue and serum samples from these patients. Human aortic smooth muscle cells were treated with AGE-BSA in gradient concentrations, and changes in phenotype and protein and mRNA levels were detected.

resultsSerum levels of sRAGE in the 3 BAV groups were obviously higher than those in the tricuspid aortic valve group, although there was negative correlation between the serum sRAGE levels and ascending aortic diameters among patients with BAV. Transcript expression levels of RAGE and NF-κBp65 mRNA were increased in the 3 BAV groups and RAGE/NF-κB pathway was activated with the progression of ascending aortic aneurysm. Abnormal activation of RAGE/NF-κB pathway was observed in AGE-BSA-treated human aortic smooth muscle cells.

conclusionsOur study has shown a trend in serum levels of sRAGE among patients with BAV, and that the cellular and extracellular pathological processes are quite serious even in the normal-sized or slightly dilated aorta. Together, the findings indicated that sRAGE may be used as a biomarker to predict aneurysm expansion rates and the risk of adverse vascular events.

Indexed as

Aortic AneurysmHeart Valve DiseasesAortic ValveGlycation End Products, AdvancedHumansNF-kappa BGlycation End Products, AdvancedNF-kappa BAortic aneurysmBicuspid aortic valveBiomarkerCirculating sRAGENF-κB pathway

Identifiers

PMID34648622
PMCPMC8766214
OpenAlexW3205957109

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.